Listar TCC por asesor "62f55b0a-2b1f-4001-927e-eee35f2be006"
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A autofagia é necessária para a segregação de DNA mitocondrial no Fígado
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 24/06/2021)Mutations in the mitochondrial genome (mtDNA) are ubiquitous in humans and can lead to a broad spectrum of disorders. However, due to the presence of multiple mtDNA molecules in the cell, coexistence of mutant and wild-type ... -
Efeito do nocaute fígado-específico da Mitofusina 2 sobre o acúmulo de DNA mitocondrial NZB/BINJ em camundongos
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 19/11/2021)The mammalian mitochondrial DNA (mtDNA) shows a high mutation frequency, which can lead to severe diseases in humans. However, disease development relies on the mutation load, which is tissue specific. This is explained ...