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Caracterização de células estromais mesenquimais multipotentes cultivadas na presença de uma molécula moduladora da expressão de ciclo-oxigenase-2
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 28/03/2019)Mesenchymal stromal cells (MSC) are stem cells used in therapeutic applications due to their regenerative and immunomodulatory potential. These cells exhibit paracrine activity, which releases soluble factors that allow ... -
Nanoformulação do [10]-Gingerol em células de câncer de mama triplo negativo
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 08/10/2020)Breast cancer is the neoplasm that most affects women worldwide and can be classified into different types. Among them, triple negative breast cancer (TN) is characterized by not having hormone receptors, nor receptors for ... -
Avaliação do potencial antimicrobiano de nanoemulsões à base de compostos de óleos essenciais no controle de espécies de Xanthomonas causadoras do cancro cítrico
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 27/11/2020)Citrus canker is one of the most relevant diseases that affect citrus crops, being responsible for serious economic losses to citrus fruit producers and traders. This disease is caused by Gram-negative bacteria of the genus ... -
Produção e avaliação de anticorpo policlonal anti-Leishmania para aplicação em diagnóstico
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 18/12/2020)Leishmania is a protozoa genus with several species of intracellular parasites that cause diseases called leishmaniasis, divided into: visceral (VL), the most serious form that affects internal organs and can lead to death, ... -
Aplicabilidade clínica da técnica CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) no tratamento da anemia falciforme: uma revisão integrativa
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 18/12/2020)Introduction and objective: Sickle cell disease is the most common hemoglobinopathy in humans and has a high morbidity and mortality rates. It is caused by a point mutation, an A-T substitution (GAG→GTG) in the first exon ... -
Análise in silico de um novo composto possível inibidor de ciclooxigenase 2 utilizando docking molecular
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 04/01/2021)This work describes the study of the formation of complexes between the enzyme cyclooxygenase (COX-2) and some of its inhibitors. For this purpose, the known inhibitors celecoxib (CEL), rofecoxib (RCX) and Korean 21 and ... -
Clonagem e expressão de uma xilanase presente no (Meta)transcriptoma do Cupim da espécie Heterotermes tenuis e sua importante aplicação na produção de biocombustíveis
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 08/01/2021)Xylanases are an important group of enzymes responsible for the hydrolysis of the xylan glycosidic chain forming xylose and xylobiosis. Mainly noteworthy is endo-1,4-β-xylanase, a hemicellulase capable of cleaving the β-1,4 ... -
Manipulação das condições ambientais em culturas de Kirchneriella contorta: efeitos na fotossíntese e no rendimento de biomoléculas de valor agregado
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 12/01/2021)Microalgae are a natural source of valuable products and have the potential to be applied in several productive sectors. Among the wide range of biomolecules that synthesize, carbohydrates, proteins and lipids, including ... -
Reflexões sobre o papel dos valores nas aplicações biotecnológicas
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 29/01/2021)Biotechnology is the central object of study, it will be classified here as an activity originated in the boundary between science (chemical and biological) and engineering, under the influence of several sets of values, ... -
Efeito da administração de esteroides anabólico-androgênicos sobre vias metabólicas e alterações morfológicas no tecido muscular esquelético exercitado
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 05/05/2021)The present study, as a descriptive review, aimed to comprehend the effects of the exogenous anabolic-androgenic administration on metabolic pathways, as well as the physiological modulation of the exercised skeletal muscle ... -
Predição de proteínas parceiras de interação da trealase, enzima relacionada com a patogenicidade de Xanthomonas citri subsp. citri
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 17/06/2021)Known as one of the main phytopathologies that affect the citrus industry worldwide, citrus canker is caused by the bacterium Xanthomonas citri subsp. citri (XAC) and is responsible for causing premature drop and reduction ... -
Estudo sobre a ativação dos receptores canabinoides na função cardíaca de matrinxã, Brycon amazonicus: expressão de proteínas envolvidas no manejo do cálcio
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 18/06/2021)This study aimed to evaluate the effects of activation of CB1 and CB2 receptors on proteins involved in myocardial calcium handling of the tropical fish matrinxã, Brycon amazonicus. Three experimental groups were employed: ... -
Potencial de fungos endofíticos no controle de doenças pós-colheita de frutas
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 18/06/2021)Postharvest losses are significant to the agricultural production yield and generate a considerable amount of food losses every year in a world constantly affected by starvation and food unsafety. Moreover, sustainable ... -
Acinetobacter baumannii: por que novos antibióticos são necessários ?
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 21/06/2021)Acinetobacter baumannii, an opportunistic gram-negative coccobacillus bacterium belonging to the genus Acinetobacter, has gained worldwide importance as a public health problem. This bacterium has an extraordinary ability ... -
Mecanismos de regulação gênica relacionados a eficiência alimentar em bovinos da raça Nelore
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 23/06/2021)Brazil is one of the main beef producers and exporters, with herds predominantly composed of Nellore Zebu animals (Bos indicus). In this scenario, genomics can contribute to the identification of potential biomarkers of ... -
A autofagia é necessária para a segregação de DNA mitocondrial no Fígado
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 24/06/2021)Mutations in the mitochondrial genome (mtDNA) are ubiquitous in humans and can lead to a broad spectrum of disorders. However, due to the presence of multiple mtDNA molecules in the cell, coexistence of mutant and wild-type ... -
Avaliação do co-cultivo de bactérias e microalga Chlorella sorokiniana no tratamento de efluentes
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 03/09/2021)Pollution is a social and health problem, the lack of sewer treatment together with its incorrect disposal are one of the leading sources of aquatic pollution. Microalgae are microorganisms which have the potential for ... -
Estudos in silico da formação de complexos de alguns fármacos relacionados com a obesidade e potenciais receptores-alvo
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 09/11/2021)Obesity is a global health problem in the most diverse geographic locations at all socioeconomic levels that affects several physiological functions and increases the risk of cardiovascular diseases, tumors, musculoskeletal ... -
Os cromossomos sexuais como fonte geradora de diferenciação genética. O gênero Pyrrhulina (Characiformes, Lebiasinidae) como modelo
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 11/11/2021)Allopatric processes are generally considered among the main causes of the striking Neotropical biodiversity. However, the role of chromosomal rearrangements and neo-sex chromosomes in genetic diversity and speciation ... -
Aumento da produção de fenazina-1-ácido carboxílico em E. coli: efeito da superexpressão dos genes tktA e ppsA
(Universidade Federal de São Carlos, UFSCar, , Câmpus São Carlos, 11/11/2021)Secondary metabolites known as phenazines are nitrogenated aromatic compounds produced particularly by the bacterium genera Pseudomonas and Streptomyces, with applications in fields like biological pest control and biosensors ...