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Terapia fágica e entrega de sistemas CRISPR-Cas9 Tipo II programáveis como alternativa ao uso de antibióticos no combate a Staphylococcus aureus: revisão sistemática da literatura
(Universidade Federal de São Carlos, 2022-09-26)
Staphylococcus aureus is a commensal bacterium of both the skin and the human mucosa, but also a frequent cause of serious infections with high morbidity, mortality and associated health costs. S. aureus strains have the ...
Caracterização parcial e imobilização covalente da Neutrase® comercial
(Universidade Federal de São Carlos, 2023-02-02)
The use of enzymes as agents for modifying the functional properties of proteins has been widespread, mainly in the food industry. One of the most studied groups for this purpose are the proteases. Proteases are responsible ...
Silenciamento do gene itgb3 de células de tumor de mama murino triplo negativo (4T1BM2)
(Universidade Federal de São Carlos, 2022-09-14)
Breast cancer is the most recurrent type of tumor in the world, surpassing lung cancer, according to data published in 2021 by the World Health Organization (WHO). When tumor cells spread or invade nearby or distant tissues, ...
Caracterização de uma cepa do gênero Brevundimonas multidroga resistente, isolada de um paciente na Unidade de Terapia Intensiva, usando sequenciamento completo do genoma
(Universidade Federal de São Carlos, 2023-03-30)
Brevundimonas species have been considered an opportunistic human pathogen that can cause invasive and severe infections in patients with underlying pathologies. In order to increase our knowledge about these pathogens, ...
Predição de proteínas parceiras de interação da trealase, enzima relacionada com a patogenicidade de Xanthomonas citri subsp. citri
(Universidade Federal de São Carlos, 2021-06-17)
Known as one of the main phytopathologies that affect the citrus industry worldwide, citrus canker is caused by the bacterium Xanthomonas citri subsp. citri (XAC) and is responsible for causing premature drop and reduction ...
Acinetobacter baumannii: por que novos antibióticos são necessários ?
(Universidade Federal de São Carlos, 2021-06-21)
Acinetobacter baumannii, an opportunistic gram-negative coccobacillus bacterium belonging to the genus Acinetobacter, has gained worldwide importance as a public health problem. This bacterium has an extraordinary ability ...
Potencial de fungos endofíticos no controle de doenças pós-colheita de frutas
(Universidade Federal de São Carlos, 2021-06-18)
Postharvest losses are significant to the agricultural production yield and generate a considerable amount of food losses every year in a world constantly affected by starvation and food unsafety. Moreover, sustainable ...
Avaliação do potencial antimicrobiano de nanoemulsões à base de compostos de óleos essenciais no controle de espécies de Xanthomonas causadoras do cancro cítrico
(Universidade Federal de São Carlos, 2020-11-27)
Citrus canker is one of the most relevant diseases that affect citrus crops, being responsible for serious economic losses to citrus fruit producers and traders. This disease is caused by Gram-negative bacteria of the genus ...
Investigação de moléculas híbridas para o tratamento anticâncer
(Universidade Federal de São Carlos, 2022-07-06)
Cancer is the attribution given to the uncontrolled growth and proliferation of abnormal cells capable of invading and destroying the adjacent tissue. According to the World Health Organization (WHO), the global growth in ...
A autofagia é necessária para a segregação de DNA mitocondrial no Fígado
(Universidade Federal de São Carlos, 2021-06-24)
Mutations in the mitochondrial genome (mtDNA) are ubiquitous in humans and can lead to a broad spectrum of disorders. However, due to the presence of multiple mtDNA molecules in the cell, coexistence of mutant and wild-type ...