Efeito da administração de esteroides anabólico-androgênicos sobre vias metabólicas e alterações morfológicas no tecido muscular esquelético exercitado

Abstract

The present study, as a descriptive review, aimed to comprehend the effects of the exogenous anabolic-androgenic administration on metabolic pathways, as well as the physiological modulation of the exercised skeletal muscle tissue by these drugs, elucidating biochemical pathways and the details of the endocrine and muscular morphophysiology, given the action of androgenic hormones (AAS), such as testosterone and its derivatives. First used exclusively for medicinal purposes, the anabolic-androgenic steroids have gone through an accentuated increase in their use from the 1950s on, mainly by athletes, and years later for aesthetical purposes. Still considered a sensitive issue in many countries, there is a lack of information counting on a wide statistical range over the effects these drugs may cause in the metabolism and the key points that connect the hypertrophy mechanisms. Given this scenario, this study pursued to explore the many aspects involved in the exogenous androgens administration for athletic performance or aesthetics, aside from quoting different perspectives of how researches involving AAS help to build a better comprehension of health issues beyond muscular hypertrophy, such as metabolic syndromes and obesity, for instance.