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Non-invasive ventilation improves exercise tolerance and peripheral vascular function after high-intensity exercise in COPD-HF patients

dc.contributor.authorGoulart, Cássia da Luz
dc.contributor.authorCaruso, Flávia Rossi
dc.contributor.authorAraújo, Adriana Sanches Garcia de
dc.contributor.authorArêas, Guilherme Peixoto Tinoco
dc.contributor.authorMoura, Silvia Cristina Garcia de
dc.contributor.authorCatai, Aparecida Maria
dc.contributor.authorMendes, Renata Gonçalves
dc.contributor.authorPhillips, Shane A.
dc.contributor.authorArena, Ross
dc.contributor.authorSilva, Andréa Lúcia Gonçalves da
dc.contributor.authorSilva, Audrey Borghi
dc.date.accessioned2022-02-10T09:42:27Z
dc.date.available2022-02-10T09:42:27Z
dc.date.issued2020-09-25
dc.identifierhttps://doi.org/10.1016/j.rmed.2020.106173por
dc.identifier.citationGOULART, Cássia da Luz; CARUSO, Flávia Rossi; ARAÚJO, Adriana Sanches Garcia de; ARÊAS, Guilherme Peixoto Tinoco; MOURA, Silvia Cristina Garcia de; CATAI, Aparecida Maria; MENDES, Renata Gonçalves; PHILLIPS, Shane A.; ARENA, Ross; SILVA, Andréa Lúcia Gonçalves da; SILVA, Audrey Borghi. Non-invasive ventilation improves exercise tolerance and peripheral vascular function after high-intensity exercise in COPD-HF patients. Repositório Institucional da UFSCar, 2020. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15580.*
dc.identifier.urihttps://repositorio.ufscar.br/handle/ufscar/15580
dc.descriptionAim: Evaluate the acute effects of non-invasive positive pressure ventilation (NiPPV) during high-intensity exercise on endothelial function in patients with coexisting chronic obstructive pulmonary disease (COPD) and heart failure (HF). Methods: This is a randomized, double blinded, sham-controlled study involving 14 COPD-HF patients, who underwent a lung function test and Doppler echocardiography. On two different days, patients performed incremental cardiopulmonary exercise testing (CPET) and two constant-work rate tests (80% of CPET peak) receiving Sham or NiPPV (bilevel mode - Astral 150) in a random order until the limit of tolerance (Tlim). Endothelial function was evaluated by flow mediated vasodilation (FMD) at three time points: 1) Baseline; 2) immediately post-exercise with NiPPV; and 3) immediately post-exercise with Sham. Results: Our patients had a mean age of 70 ± 7 years, FEV1 1.9 ± 0.7 L and LVEF 41 ± 9%. NIPPV resulted in an increased Tlim (NiPPV: 130 ± 29s vs Sham: 98 ± 29s p = 0.015) and SpO2 (NiPPV: 94.7 ± 3.5% vs Sham: 92.7 ± 5.2% p = 0.03). Also, NiPPV was able to produce a significant increase in FMD (%) (NiPPV: 9.2 ± 3.1 vs Sham: 3.6 ± 0.7, p < 0.05), FMD (mm) (NiPPV: 0.41 ± 0.18 vs Sham: 0.20 ± 0.11, p < 0.05), Blood flow velocity (NiPPV: 33 ± 18 vs Baseline: 20 ± 14, p < 0.05) and Shear Stress (SS) (NiPPV: 72 ± 38 vs Baseline: 43 ± 25, p < 0.05). We found correlation between Tlim vs. ΔSS (p = 0.03; r = 0.57). Univariate-regression analysis revealed that increased SS influenced 32% of Tlim during exercise with NiPPV. Conclusion: NiPPV applied during high-intensity exercise can acutely modulate endothelial function and improve exercise tolerance in COPD-HF patients. In addition, the increase of SS positively influences exercise tolerance.eng
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)por
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)por
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.language.isoengeng
dc.publisherUniversidade Federal de São Carlospor
dc.relation.urihttps://pubmed.ncbi.nlm.nih.gov/33007709por
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectCOPDeng
dc.subjectEndothelial functioneng
dc.subjectExercise testeng
dc.subjectHeart failureeng
dc.subjectVentilationeng
dc.titleNon-invasive ventilation improves exercise tolerance and peripheral vascular function after high-intensity exercise in COPD-HF patientseng
dc.typeDataseteng
dc.publisher.initialsUFSCarpor
dc.publisher.programPrograma de Pós-Graduação em Fisioterapia - PPGFtpor
dc.subject.cnpqCIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONALpor
dc.description.sponsorshipIdProcesso nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.description.sponsorshipIdCódigo de Financiamento 001 - CAPESpor
dc.description.sponsorshipIdProcesso nº 141803/ 2019 -3 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)por
dc.description.sponsorshipIdProcesso nº 2018/03233-0, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.publisher.addressCâmpus São Carlospor
dc.contributor.authorlatteshttp://lattes.cnpq.br/9790656360225486por
dc.contributor.authorlatteshttp://lattes.cnpq.br/7119400854907214por
dc.contributor.authorlatteshttp://lattes.cnpq.br/0104886088821769por
dc.contributor.authorlatteshttp://lattes.cnpq.br/0833133191438250por
dc.contributor.authorlatteshttp://lattes.cnpq.br/1044361149989467por
dc.contributor.authorlatteshttp://lattes.cnpq.br/5801652590531684por
dc.contributor.authorlatteshttp://lattes.cnpq.br/9634590922242052por
dc.contributor.authorlatteshttp://lattes.cnpq.br/5625129949363675por
dc.contributor.authorlatteshttp://lattes.cnpq.br/4855616925791895por
dc.publisher.departmentDepartamento de Fisioterapia - DFisiopor


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