Do the oxidative stress biomarkers predict COVID-19 outcome? An in-hospital cohort study
Fecha
2023-07-15Autor
Neves, Fabio Fernandes
Pott-Junior, Henrique
Yamashita, Kaori Maria Carolina
Santos, Sigrid de Sousa
Cominetti, Marcia Regina
Freire, Caio Cesar de Melo
Cunha, Anderson Ferreira
Jordão Júnior, Alceu Afonso
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In SARSCoV-2 infections, excessive activation of the immune system dramatically elevates reactive oxygen species levels, harms cell structures, and directly increases disease severity and mortality. We aimed to evaluate whether plasma oxidative stress biomarker levels could predict mortality in adults admitted with Coronavirus Disease 2019 (COVID-19), considering potential confounders. We conducted a cohort study of 115 adults (62.1 ± 17.6 years, 65 males) admitted to a Brazilian public hospital for severely symptomatic COVID-19. Serum levels of α-tocopherol, glutathione, superoxide dismutase, 8-hydroxy-2′-deoxyguanosine, malondialdehyde, and advanced oxidation protein products were quantified at COVID-19 diagnosis using real-time polymerase chain reaction. Serum levels of α-tocopherol, glutathione, superoxide dismutase, and advanced oxidation protein products differed significantly between survivors and non-survivors. Serum glutathione levels below 327.2 μmol/mL were associated with a significant risk of death in COVID-19 patients, even after accounting for other factors (adjusted hazard ratio = 3.12 [95% CI: 1.83–5.33]).
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