Alcalóides de Rutaceae: química e atividade biológica.
Resumen
This
work describes the phytochemical study of two plant species Galipea bracteata and
Ravenia infelix belonging to the family Rutaceae, aiming the isolation and structure
determination of componds from leaves and branches of these plants. This work is
also directed to the search of trypanocidal and leishmanicidal compounds from these
plants. The following models were used to check the biological activities of the
isolated compounds: antiparasitc activity - trypomastigote form of Trypanosoma cruzi
in vitro , enzymatic inhibitory activity on gGAPDH (Glyceraldeyde 3- phosphate
dehidrogenase) of T. cruzi and enzymatic inhibitory activity on APRT (Adheninephosphoribosyl-
transferase) of Leishmania tarentolae. The leaves extract of G.
bracteata afforded tirtheen quinoline alkaloids. Among these compounds seven have
been described for the first time: 2-(3 ,4 -methylenedioxyphenylethyl)quinoline, 4-
methoxy-2-(propan-1 -ona)quinoline (inedit), 4-methoxy-2-(1 ,2 -transepoxypentyl)
quinoline (inedit), 4-methoxy-2-n-heptylquinoline, 2-(1 ,2 -transepoxypentyl)
quinoline (inedit), 4-methoxy-2-(3 ,4 -
methylenedioxyphenylethyl)quinoline, 4-methoxy-2-(1 ,2 -trans-epoxypropyl)quinoline
(inedit), 4-methoxy-2-n-propylquinoline, 2-n-pentylquinoline, 2-(propan-1 -
one)quinoline (inedit), 4-methoxy-2-(pentan-1 -one)quinoline (inedit), 2-(pentan-1 -
one)quinoline (inedit), a mixture of steroids campesterol, stigmasterol and sitosterol,
one furoquinoline alkaloid evolitrine, a mixture of seco-furoquinoline alkaloids Edimethylrhoifolinate
and Z-dimethylrhoifolinate, a pentacylclic triterpene arborinol and
norsesquiterpene 3,5-dihydromegastigma-6,7-diene-9-one. From the branches of R.
Infelix were isolated the carbazole alkaloids: 3-methylcarbazole and girinimbin, the
steroids: 7-oxo-stigmasterol and 7-oxo-sitosterol, the indol 3-carboxaldeheide and
mixtures of amides: N-trans and N-cis-feruloyltyramine, and N-trans and-cis-pcumaroyltyramine.
The pure compounds had their trypanocidal and leishmanicidal
activities determined.