Os efeitos do treinamento resistido e da reposição com estradiol em ratas ovariectomizadas sobre a glicemia, insulinemia e morfologia de adipócitos

Abstract

Ovariectomy (OVX) in rats simulates menopause and results in decreased levels of estrogen, and may be associated with morbidities such as central obesity and metabolic abnormalities. (TR) in the adipocyte area of the mesenteric and retroperitoneal deposits and in the insulin sensitivity of OVX rats. Thirty female Sprague-Dowley rats were divided into 5 groups: Sham-Sedentary (Sham-Sed), Ovariectomized-Sedentary (Ovx-Sed), Sham-Treated (Sham-TR), Ovariectomized-Trained (Ovx-TR) and Ovariectomized- Sedentary-Replacement (Ovx-Sed-RE). ER was made by silastic capsules containing 17β-estradiol at weeks 0 and 6. The RT lasted for 12 weeks. The morphology was evaluated by histological analysis. As ovariectomized rats (Ovx-Sed, Ovx-TR) presented higher body mass and body fat when compared to the Sham-Sed group. As concentrations of glucose and insulin are similar in all experimental groups. As OVX rats presented greater area of adipocytes in the mesenteric and retroperitoneal deposits and as trained rats showed a smaller area of the adipocytes in the same deposits. However, most of the receptors were observed in animals treated with both mesenteric and retroperitoneal deposits, thus suggesting that estradiol replacement may have been performed at supraphysiological doses. It was concluded that OVX rats submitted to 12 weeks of RT present lower body mass and adipocyte area in the mesenteric and retroperitoneal deposits.