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Investigação do tratamento com N-acetilcisteína nos comportamentos relacionados à ansiedade durante a síndrome de abstinência do etanol e na resposta cardiovascular induzida pelo estresse em ratos
(Universidade Federal de São Carlos, 2019-02-08)
N-acetylcysteine (NAC) for decades, has been shown to have beneficial effects for the treatment of some diseases. Recently, based on central glutamatergic neurotransmission, psychiatric disorders and the stress response ...
Análise etofarmacológica do labirinto em cruz elevado aberto para avaliar comportamentos defensivos e a antinocicepção induzida pelo medo em camundongos
(Universidade Federal de São Carlos, 2013-04-12)
Exposure of rodents to an open elevated plus-maze (oEPM) elicits antinociception and increases plasma corticosterone levels. However, no studies have yet assessed the defensive behaviour repertoire of animals in this ...
Análise etofarmacológica de um novo teste de interação presa-predador : o teste de exposição ao rato
(Universidade Federal de São Carlos, 2013-05-23)
The rat exposure test (RET) is a new ethological model of predator-prey with interactions between the rat and the mouse. The RET allows the expression of defensive behaviors in the prey. The experimental apparatus is ...
Papel do cortex pré-frontal medial no comportamento defensivo de camundongos : avaliação farmacológica da lateralização funcional
(Universidade Federal de São Carlos, 2017-04-13)
Stressful situations are risk factors to the development of neuropsychiatric diseases, as anxiety disorders. However, not everyone who experiences stressful events develops stress-related illness. That is due to the existence ...
Avaliação do modelo de transtorno de estresse póstraumático (TEPT) e camundongos machos : efeitos do midazolam, sertralina e ausência de efeito da imipramina
(Universidade Federal de São Carlos, 2008-05-21)
The post-traumatic stress disorder (PTSD) affects a portion of subjects exposed to a traumatic event. This disorder leads to long-term alterations in the hypothalamus-pituitaryadrenal (HPA) axis, autonomic and cognitive ...
O papel dos receptores 5-HT3 da amídala na modulação da ansiedade em camundongos expostos ao labirinto em cruz elevado
(Universidade Federal de São Carlos, 2010-05-07)
Aversive situations may activate the serotonergic system, which, in turn, emit projections to structures involved in the defense mechanisms such as: septum, hypothalamus, hippocampus, periaqueductal gray and amygdala, ...
Avaliação do papel dos receptores 5-HT3 da substância cinzenta periaquedutal de camundongos submetidos ao labirinto em cruz elevado
(Universidade Federal de São Carlos, 2009-04-24)
The exposure of animals to aversive situations, such as elevated plus-maze (EPM), activates serotonergic pathways with projections into structures involved in the defense system, such as the amygdala, septum, hypothalamus, ...
Avaliação do papel dos receptores 5-ht2 da substância cinzenta periaquedutal de camundongos submetidos ao labirinto em cruz elevado
(Universidade Federal de São Carlos, 2008-03-28)
It is widely acknowledged that the indoleamine neurotransmitter serotonin (5-HT)
plays a dual role in the regulation of anxiety, a role that in part depends upon neuroanatomical
locus of action. Thus, whereas stimulation ...
Efeito do extrato bruto e da fração alcaloídica de Erythrina velutina em camundongos submetidos ao labirinto em cruz elevado e ao modelo de esquiva inibitória do tipo descida da plataforma
(Universidade Federal de São Carlos, 2009-08-11)
In the popular therapy Erythrina velutina (EV), plant family Fabaceae, is used as an analgesic, anticonvulsant, anxiolytic or sedative and combating insomnia. Previous studies performed in rodents suggest that extracts of ...
O ondansetron, antagonista dos receptores 5-HT3, reverte o efeito ansiolítico das injeções de midazolam no hipocampo ventral de camundongos expostos aos modelos labirinto em cruz elevado (LCE) e exposição ao rato
(Universidade Federal de São Carlos, 2012-02-10)
Animal models have often been used to investigate the neurobiology of emotional states (fear and anxiety). In this sense, the elevated plus maze (EPM) and the rat exposure test are effective to evaluate these states and ...