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Investigação do tratamento com N-acetilcisteína nos comportamentos relacionados à ansiedade durante a síndrome de abstinência do etanol e na resposta cardiovascular induzida pelo estresse em ratos
(Universidade Federal de São Carlos, 2019-02-08)
N-acetylcysteine (NAC) for decades, has been shown to have beneficial effects for the treatment of some diseases. Recently, based on central glutamatergic neurotransmission, psychiatric disorders and the stress response ...
Análise etofarmacológica do labirinto em cruz elevado aberto para avaliar comportamentos defensivos e a antinocicepção induzida pelo medo em camundongos
(Universidade Federal de São Carlos, 2013-04-12)
Exposure of rodents to an open elevated plus-maze (oEPM) elicits antinociception and increases plasma corticosterone levels. However, no studies have yet assessed the defensive behaviour repertoire of animals in this ...
Análise etofarmacológica de um novo teste de interação presa-predador : o teste de exposição ao rato
(Universidade Federal de São Carlos, 2013-05-23)
The rat exposure test (RET) is a new ethological model of predator-prey with interactions between the rat and the mouse. The RET allows the expression of defensive behaviors in the prey. The experimental apparatus is ...
O bloqueio dos receptores glicocorticóides da região infralímbica do córtex pré-frontal medial facilita a aquisição, mas não a consolidação da memória de camundongos submetidos ao protocolo de teste e reteste no labirinto em cruz elevado
(Universidade Federal de São Carlos, 2018-09-21)
A single experience (test) in the elevated plus maze (EPM) increases the avoidance of open arms and impairs the anxiolytic efficacy of the midazolam benzodiazepine agonist (MDZ) in a subsequent re-esposition (retest). ...
Papel do córtex pré-frontal medial na ansiogênese induzida pelo estresse de derrota social em camundongos
(Universidade Federal de São Carlos, 2018-10-18)
Recent findings have demonstrated that the medial prefrontal cortex (mPFC) has a lateralized role in the control of response to stressors, and the left hemisphere (LmPFC) would attenuate the anxiogenic responses elicited ...
Papel do cortex pré-frontal medial no comportamento defensivo de camundongos : avaliação farmacológica da lateralização funcional
(Universidade Federal de São Carlos, 2017-04-13)
Stressful situations are risk factors to the development of neuropsychiatric diseases, as anxiety disorders. However, not everyone who experiences stressful events develops stress-related illness. That is due to the existence ...
Avaliação do papel dos receptores 5-HT3 da substância cinzenta periaquedutal de camundongos submetidos ao labirinto em cruz elevado
(Universidade Federal de São Carlos, 2009-04-24)
The exposure of animals to aversive situations, such as elevated plus-maze (EPM), activates serotonergic pathways with projections into structures involved in the defense system, such as the amygdala, septum, hypothalamus, ...
Efeito do extrato bruto e da fração alcaloídica de Erythrina velutina em camundongos submetidos ao labirinto em cruz elevado e ao modelo de esquiva inibitória do tipo descida da plataforma
(Universidade Federal de São Carlos, 2009-08-11)
In the popular therapy Erythrina velutina (EV), plant family Fabaceae, is used as an analgesic, anticonvulsant, anxiolytic or sedative and combating insomnia. Previous studies performed in rodents suggest that extracts of ...
Avaliação do modelo de transtorno de estresse póstraumático (TEPT) e camundongos machos : efeitos do midazolam, sertralina e ausência de efeito da imipramina
(Universidade Federal de São Carlos, 2008-05-21)
The post-traumatic stress disorder (PTSD) affects a portion of subjects exposed to a traumatic event. This disorder leads to long-term alterations in the hypothalamus-pituitaryadrenal (HPA) axis, autonomic and cognitive ...
Avaliação do papel dos receptores 5-ht2 da substância cinzenta periaquedutal de camundongos submetidos ao labirinto em cruz elevado
(Universidade Federal de São Carlos, 2008-03-28)
It is widely acknowledged that the indoleamine neurotransmitter serotonin (5-HT)
plays a dual role in the regulation of anxiety, a role that in part depends upon neuroanatomical
locus of action. Thus, whereas stimulation ...