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Papel do córtex pré-frontal medial na ansiogênese induzida pelo estresse de derrota social em camundongos
(Universidade Federal de São Carlos, 2018-10-18)
Recent findings have demonstrated that the medial prefrontal cortex (mPFC) has a lateralized role in the control of response to stressors, and the left hemisphere (LmPFC) would attenuate the anxiogenic responses elicited ...
O bloqueio dos receptores glicocorticóides da região infralímbica do córtex pré-frontal medial facilita a aquisição, mas não a consolidação da memória de camundongos submetidos ao protocolo de teste e reteste no labirinto em cruz elevado
(Universidade Federal de São Carlos, 2018-09-21)
A single experience (test) in the elevated plus maze (EPM) increases the avoidance of open arms and impairs the anxiolytic efficacy of the midazolam benzodiazepine agonist (MDZ) in a subsequent re-esposition (retest). ...
Administração do 8-OH-DPAT no septo dorso lateral de camundongos submetidos ao labirinto em cruz elevado promove efeito ansiolítico que é revertido pelo pré-tratamento local com WAY100635
(Universidade Federal de São Carlos, 2010-08-13)
Research on anxiety often involves the use of animal models for investigation of therapeutic compounds. Thus, the elevated plus maze (EPM) is one of the most commonly model used in research involving anxiety and it has ...
Bloqueio dos receptores 5-HT2 da substância cinzenta periaquedutal suprime o efeito ansiolítico resultante do antagonismo dos receptores 5-HT1A do núcleo mediano da rafe em camundongos
(Universidade Federal de São Carlos, 2011-12-15)
Several lines of evidence support the involvement of serotonergic (5-HT) neurons of the median raphe nucleus (MRN) in anxiety-like behaviour. In this context, it is known that blockade of 5- HT1A somatodendritic autoreceptors ...
O bloqueio dos receptores NMDA ou CRF1 no núcleo intersticial da estria terminal impede a ansiogênese induzida pela ativação nitrérgica do córtex pré-frontal medial e derrota social em camundongos
(Universidade Federal de São Carlos, 2019-09-20)
Nitric oxide (NO) release in the right medial prefrontal cortex (RmPFC) produces anxiogenesis. In the bed nucleus of the stria terminalis (BNST), a region that receives neuronal projections from the mPFC, NO also provokes ...
Papel dos receptores vaniloides TRPV1 da matéria cinzenta periaquedutal na ansiedade e na antinocicepção induzida pelo medo em camundongos
(Universidade Federal de São Carlos, 2013-05-03)
When confronted with fear situations rodents exhibit behavioral (e.g., fight, flight, immobility and vocalization) and neurovegetative (tachycardia, hypertension and defecation) responses that characterize the defense ...
O ondansetron, antagonista dos receptores 5-HT3, reverte o efeito ansiolítico das injeções de midazolam no hipocampo ventral de camundongos expostos aos modelos labirinto em cruz elevado (LCE) e exposição ao rato
(Universidade Federal de São Carlos, 2012-02-10)
Animal models have often been used to investigate the neurobiology of emotional states (fear and anxiety). In this sense, the elevated plus maze (EPM) and the rat exposure test are effective to evaluate these states and ...
Efeito ansiolítico do ondansetron, antagonista dos receptores 5-HT3, injetado na amídala de camundongos submetidos à exposição e reexposição no labirinto em cruz elevado
(Universidade Federal de São Carlos, 2011-03-02)
Against of stimuli that are dangerous, animals manifest defense reactions that cause fear and anxiety. These stimuli activate the serotonergic system, which sends projections to structures involved in defense mechanisms ...
Envolvimento de neurotransmissões angiotensinérgicas no núcleo medial da amídala nas respostas cardiovasculares e ansiogênica ao estresse de restrição em ratos
(Universidade Federal de São Carlos, 2020-09-04)
Limbic structures participate in the control of physiological responses related to stress, and the medial amigdaloid nucleus (MeA) has been demonstrated as an area of the central nervous system involved in the control these ...
Papel do cortex pré-frontal medial no comportamento defensivo de camundongos : avaliação farmacológica da lateralização funcional
(Universidade Federal de São Carlos, 2017-04-13)
Stressful situations are risk factors to the development of neuropsychiatric diseases, as anxiety disorders. However, not everyone who experiences stressful events develops stress-related illness. That is due to the existence ...