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Endothelial function provides early prognostic information in patients with COVID-19: a cohort study

dc.contributor.authorOliveira, Murilo Rezende
dc.contributor.authorBack, Guilherme Dionir
dc.contributor.authorGoulart, Cássia da Luz
dc.contributor.authorDomingos, Bianca Cristina
dc.contributor.authorArena, Ross
dc.contributor.authorSilva, Audrey Borghi
dc.date.accessioned2022-02-10T09:47:00Z
dc.date.available2022-02-10T09:47:00Z
dc.date.issued2021-05-23
dc.identifierhttps://doi.org/10.1016/j.rmed.2021.106469por
dc.identifier.citationOLIVEIRA, Murilo Rezende; BACK, Guilherme Dionir; GOULART, Cássia da Luz; DOMINGOS, Bianca Cristina; ARENA, Ross; SILVA, Audrey Borghi. Endothelial function provides early prognostic information in patients with COVID-19: a cohort study. Repositório Institucional da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15581.*
dc.identifier.urihttps://repositorio.ufscar.br/handle/ufscar/15581
dc.descriptionBackground: The prothrombotic phenotype and diffuse intravascular coagulation observed in COVID-19 reflect endothelial dysfunction, which is linked to blood flow delivery deficiencies and cardiovascular risk. Assessments of detect vascular deficiencies among newly diagnosed and hospitalized patients due to COVID-19 have yet to be determined. Objective: To assess endothelial function characteristics in relation to length of hospitalization and mortality in patients diagnosed with COVID-19 and compare to patients without COVID-19. Methods: A prospective observational study involving 180 patients with confirmed COVID-19 (COVID-19 group) or suspected and ruled out COVID-19 (Non-COVID-19 group). Clinical evaluation and flow mediated vasodilation (FMD) were performed between the first 24-48 h of hospitalization. Patients were followed until death or discharge. Results: We evaluated 98 patients (COVID-19 group) and 82 (Non-COVID-19 group), COVID-19 group remained hospitalized longer and more deaths occurred compared to the Non-COVID-19 group (p = 0.01; and p < 0.01). Patients in COVID-19 group also had a significantly greater reduction in both FMDmm and FMD% (p < 0.01 in both). We found that absolute FMD≤0.26 mm and relative FMD≤3.43% were the ideal cutoff point to predict mortality and longer hospital stay. In Kaplan Meyer's analysis patients had a high probability of death within a period of up to 10 days of hospitalization. Conclusion: Patients hospitalized for COVID-19 present endothelial vascular dysfunction early, remained hospitalized longer and had a higher number of deaths, when compared with patients without COVID-19.eng
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)por
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)por
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.language.isoengeng
dc.publisherUniversidade Federal de São Carlospor
dc.relation.urihttps://www.resmedjournal.com/article/S0954-6111(21)00175-X/fulltextpor
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectCOVID-19eng
dc.subjectEndotheliumeng
dc.subjectFlow-mediated dilation (FMD)eng
dc.subjectHospitalizationeng
dc.titleEndothelial function provides early prognostic information in patients with COVID-19: a cohort studyeng
dc.typeDataseteng
dc.publisher.initialsUFSCarpor
dc.publisher.programPrograma de Pós-Graduação em Fisioterapia - PPGFtpor
dc.subject.cnpqCIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONALpor
dc.description.sponsorshipIdProcesso nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.description.sponsorshipIdProcesso nº 2018/03233-0, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.description.sponsorshipIdCódigo de Financiamento 001 - CAPESpor
dc.description.sponsorshipIdProcesso nº 141803/2019 -3 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)por
dc.publisher.addressCâmpus São Carlospor
dc.contributor.authorlatteshttp://lattes.cnpq.br/6238891126104160por
dc.contributor.authorlatteshttp://lattes.cnpq.br/2787418760655662por
dc.contributor.authorlatteshttp://lattes.cnpq.br/9790656360225486por
dc.contributor.authorlatteshttp://lattes.cnpq.br/6416764834728750por
dc.contributor.authorlatteshttp://lattes.cnpq.br/4855616925791895por
dc.publisher.departmentDepartamento de Fisioterapia - DFisiopor


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