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Caracterização de mutantes de Streptomyces clavuligerus ATCC 27064 obtidos por aplicação de radiação UV e tratamento químico
(Universidade Federal de São Carlos, 2008-12-18)
The clavulanic acid is a powerful inhibitor of the beta-lactamases produced by bacterias resistants to penicillin and cefalosporin. This acid is produced industrially by strains of Streptomyces clavuligerus in complex ...
Inteligência computacional aplicada à automação de biorreator para produção de Penicilina G Acilase (PGA)
(Universidade Federal de São Carlos, 2008-07-11)
Biotechnology has presented, in the last years, a rapidly growing development. New biotechnological industrial processes are constantly introduced using different microorganisms and/or enzymes. In this context, the application ...
Estudo comparativo de precursores da PpIX (ALA e MAL) utilizados topicamente em terapia fotodinâmica
(Universidade Federal de São Carlos, 2008-08-08)
Photodynamic therapy (PDT) is a modality for treatment of tumors, and uses a combination of a drug (photosensitizer) and light in the presence of the molecular oxygen to selectively damage target tissue. In the absent of ...
Imobilização e estabilização de D-Hidantoinase para a produção de N-Carbamoil-D-Fenilglicina
(Universidade Federal de São Carlos, 2008-09-29)
Immobilization and stabilization of enzymes increases their potential for use in industrial scale. D-hydantoinases (dihidropirimidina amidrohidrolase EC 3.5.2.2) catalyze the hydrolysis of D-hydantoins, generating the ...
Avaliação de formas de preparação de estoques de trabalho na preservação de Streptomyces clavuligerus visando a produção de ácido clavulânico
(Universidade Federal de São Carlos, 2008-08-28)
A great deal of microbiological and genetic research in the pharmaceutical industry is directed towards the development of effective strategies in the handling of microorganisms
seeking the production of antibiotics that ...
Técnicas computacionais inteligentes para a inferência de estado e a otimização de cultivos de Streptococcus pneumoniae
(Universidade Federal de São Carlos, 2008-03-27)
Streptococcus pneumoniae (pneumococo) is a pathogenic bacterium that causes several infections which are aggravated by the increase of serotypes with antibiotics resistance. The development of an effective vaccine against ...
Estudo das condições de cultivo e de eletrocompetência para a transformação de Bacillus megaterium ATCC 14945
(Universidade Federal de São Carlos, 2008-03-28)
The Gram-positive genus Bacillus is of great biotechnological importance. Their
ability to secrete enzymes efficiently during fermentation is exploited for the production
of extracellular enzymes such as penicillin G acylase ...