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Estudo de condições operacionais na produção de penicilina G acilase por diferentes microrganismos
(Universidade Federal de São Carlos, 2006-12-20)
Penicillin G acylase (PGA) is an enzyme of major impact in human health for
catalyzing the deacilation of the penicillin G, to yield 6-aminopenicillanic acid (6-
APA), key intermediate in the semi-synthetic antibiotics ...
Estudo da purificação do àcido clavulânico utilizando processo contínuo de adsorsão.
(Universidade Federal de São Carlos, 2003-10-02)
Clavulanic acid (CA), a beta-lactam antibiotic, has been known for its commercial and therapeutic importance. This antibiotic is produced by an actinomicete, Streptomyces clavuligerus, and has a combined use with penicillins, ...
Abordagem estatística e computacional na otimização de meios de cultura para produção de antibióticos: o caso da cefalosporina C.
(Universidade Federal de São Carlos, 2003-10-10)
The scope of the current work was to investigate the effect of glucose, amonium acetate, DL-methionine, phosphorus, oleic acid and salt solution on the maximum specific growth rate (µmax), as well as the effect of sucrose ...
Separação de compostos com atividade antibacteriana obtidos a partir de cultivos de Streptomyces clavuligerus em meio complexo
(Universidade Federal de São Carlos, 2009-09-01)
The cephamycin C is a natural cephalosporin produced by Streptomyces clavuligerus, of great importance in the pharmaceutical industry; it is a β-lactam antibiotic that acts as an inhibitor of the cellular wall synthesis. ...
Avaliação diferencial de fatores fisiológicos e cinéticos em cultivos de linhagens de células selvagem e recombinante de Drosophila melanogaster S2
(Universidade Federal de São Carlos, 2005-09-19)
In the last 10 years the insect cell Drosophila melanogaster Schneider S2 has been increasingly used for studies of proteins recombinants. However, there is a lack of studies that involved parameters related to the use of ...
Separação e purificação do ácido clavulânico através de extração líquido-líquido seguida de adsorção em coluna de leito fixo.
(Universidade Federal de São Carlos, 2005-10-19)
A study was made of the extraction of clavulanic acid (CA) from a fermented medium and
its concentration and purification, based on a comparison of two liquid-liquid extraction
methods, followed by adsorption in a fixed ...
Estudo da expressão de lipase BTL2 de Bacillus thermocatenulatus em E. coli recombinante
(Universidade Federal de São Carlos, 2009-04-03)
Using recombinant DNA techniques, the lipase BTL2 gene of Bacillus thermocatenulatus was cloned in E. coli BL321 under control of the strong temperature-inducible λPL promoter. It
was investigated, initially, in this ...
Contribuição ao desenvolvimento de metodologia para detecção de desintegrina recombinante produzida em cultivos de células CHO-K1.
(Universidade Federal de São Carlos, 2004-06-25)
Disintegrins are proteins present in the poison of serpents that have been calling the pharmaceutical industry attention due to their capacity to prevent the progression of cancerous cells. A receiving key-protein called ...
Separação de ampicilina produzida enzimaticamente por reação entre éster metílico de fenilglicina e ácido 6-aminopenicilânico.
(Universidade Federal de São Carlos, 2003-11-07)
The separation/concentration process of the products obtained from the enzymatic synthesis of ampicillin (AMP) catalyzed by immobilized penicillin G acylase was the focus of this Thesis. Hydrophobic resin adsorption and ...
Hidrodinâmica e transferência de oxigênio em três biorreatores Airlift de circulação interna geometricamente semelhantes
(Universidade Federal de São Carlos, 2009-03-12)
Internal-loop airlift reactors (ALR) are a special class of pneumatic reactors. The use of this type of reactor has been attractive for chemical and biological reactions because of their simple construction without moving ...