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Estudo comparativo do efeito da temperatura na estabilidade e espectros de bioluminescência das luciferases de Phrixotrix hirtus e outros besouros bioluminescentes
(Universidade Federal de São Carlos, 2019-03-22)
Firefly luciferases have been extensively used as bioanalytical reagents and their cDNAs as reporter genes and bioimaging biosensors. Luciferases of fireflies, “rail-road” worm and "tec-tec" beetles, have different ...
Papel do domínio desintegrina da ADAM9 humana na modulação da migração e invasão de células tumorais
(Universidade Federal de São Carlos, 2011-02-25)
Cancer metastasis is the major cause of death, consequently studies to understand the molecular mechanisms involved in this process are essential to the knowledge of this disease. Cell migration and invasion are part of ...
Cistatinas recombinantes de cana-de-açúcar : especificidade, produção em biorreator e conservação por liofilização
(Universidade Federal de São Carlos, 2018-03-02)
Phytocystatins are inhibitors of cysteine peptidases found naturally in plants.
Sugarcane cystatins are distinguished by their high inhibitory activity and possible
biotechnological applications. In this work, a comparative ...
Mecanismos de regulação da via de sinalização Wnt pela E3 ubiquitina ligase SCF(Fbxo7)
(Universidade Federal de São Carlos, 2019-02-22)
SCF complexes are composed by Skp1, Cullin1, Rbx1 and an F-box protein (FBP), which are responsible to give specificity to the complexes, as they interact with substrates, allowing ligation of an ubiquitin molecule to the ...
Obtenção de uma desintegrina recombinante de Agkistrodon contortrix laticinctus e estudo dos efeitos de desintegrinas na expressão do fator de crescimento de endotélio vascular.
(Universidade Federal de São Carlos, 2005-02-17)
Disintegrins are snake venom proteins used in the study of integrin-mediated cellular
adhesion through integrins. Recombinant disintegrin production may notable supply faster,
larger and most homogeneous protein samples ...
Comparação transcricional dos túbulos de Malpighi e corpo gorduroso de Zophobas morio: função de AMP-CoA ligases nos túbulos e relação com lanternas de Arachnocampa luminosa
(Universidade Federal de São Carlos, 2017-10-27)
The Malpighian tubules in insects play an essential role in osmoregulation, performing transport of ions and fluids during the formation of primary urine, whereas fat body is usually associated with the intermediary ...
Degradação de matéria orgânica terrestre por microrganismos do rio Amazonas – Metagenômica e genômica populacional
(Universidade Federal de São Carlos, 2018-12-14)
Microbes from Amazon river basin represent an unexplored biodiversity, with a huge metabolic potential. This ecosystem receives large amounts of terrestrial organic matter (OM), which promotes heterotrophic microbial growth. ...
Efeito do knockout da Mitofusina 1 sobre a fertilidade de oócitos murinos
(Universidade Federal de São Carlos, 2018-08-31)
Fertility is directly related to oocyte developmental competence. In this context, oocyte mitochondria play a crucial role and have become an important target in assisted reproduction therapies. However, the molecular ...
Produção heteróloga de inibidores de pectina metil esterase (PMEI), para ensaios de inibição com PME e Invertase, enzimas intestinais do Sphenophorus levis
(Universidade Federal de São Carlos, 2018-02-20)
The pectin is a fundamental part of the cell wall from plants and it is composed mainly by 4 polysaccharides. The polysaccharide most abundant is the homogalacturonan (HG) representing up to 65% from pectin, and it is a ...
Efeito modulador do extrato total do Paenibacillus polymyxa RNC-D em macrófagos e Leishmania (Leishmania) amazonensis in vitro
(Universidade Federal de São Carlos, 2018-04-20)
Leishmaniasis is an infection caused by Leishmania gender protozoa. The treatment of the disease is generally problematic, as the drugs used on clinical practice are toxic. One of the paths in the search for new therapeutic ...