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Produção recombinante e estudos funcionais de três novas cistatinas da cana-de-açúcar e sua utilização em estudos de inibição da adesão, proliferação, migração e invasão celular
(Universidade Federal de São Carlos, 2008-02-29)
ABSTRACT
Tumor metastasis is usually a major cause of death among cancer patients.
Degradation and invasion of the extracellular matrix and basement membrane, key
steps in the metastatic process, rely on the activity of ...
Expressão heteróloga, purificação e estudo de atividade de uma proteína inibidora de cisteínio protease da cana-de-açúcar e posterior evolução in vitro pela técnica de DNA Shuffling.
(Universidade Federal de São Carlos, 2004-11-26)
Plants seem to have developed, over a long period of time, defence mechanisms against fungi and insects. One of them is the use of protease inhibitor proteins. Cystatins are proteins that inhibit specifically cysteine ...
Estudos das proteínas ligantes à DCRA e DSCR1 (envolvidas com a síndrome de Down) utilizando a metodologia do duplo-híbrido.
(Universidade Federal de São Carlos, 2003-01-24)
The genes DCRA and DSCR1 are located in the Down Syndrome Critical Region , a specific portion of human chromosome 21 responsible for the main traits of the disease. In the present work we have used the two-hybrid system ...
Expressão heteróloga e localização subcelular de seis proteínas possivelmente envolvidas com a Síndrome de Down.
(Universidade Federal de São Carlos, 2004-12-07)
Down syndrome (DS) is the most common congenital disease occurring in
approximately 1 out of 700 live births. In addition to the full HC21 trisomy, rare
individuals with clinically recognized DS have only a partial trisomy, ...
Estudos moleculares da Selenocisteína Sintase (SELA) de Escherichia coli.
(Universidade Federal de São Carlos, 2005-05-05)
The study of translation processes attracts the interest of a wide range of
research groups due to its main role in general cellular metabolism. In
particular, the investigation of new amino acid residues, such as ...