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Análise do transcriptoma da glândula venenífera de Rhinocerophis alternatus (Bothrops alternatus): identificação de metaloproteases e desintegrinas
(Universidade Federal de São Carlos, 2011-03-04)
The desintegrinas are cys-rich polypeptides without enzymatic activity, some found in snake venoms with an adhesive motif to integrin, unleashing distinct responses. Several research groups have been studying snake venom ...
Análise da expressão da metalotioneína em duas espécies de peixes, Oreochromis niloticus e Prochilodus lineatus
(Universidade Federal de São Carlos, 2008-04-18)
Metallothioneins (MT) are non enzymatic proteins with with metal-binding ability. It has been
used as a biomarker for environmental pollution by the analysis of its expression in several fish
species. The tilapia is a ...
Papel do domínio desintegrina da ADAM9 humana na modulação da migração e invasão de células tumorais
(Universidade Federal de São Carlos, 2011-02-25)
Cancer metastasis is the major cause of death, consequently studies to understand the molecular mechanisms involved in this process are essential to the knowledge of this disease. Cell migration and invasion are part of ...
Produção recombinante e caracterização de uma desintegrina da peçonha de Rhinocerophis alternatus (antiga Bothrops alternatus) com atividade antimetastática visando o desenvolvimento de um novo fármaco
(Universidade Federal de São Carlos, 2011-06-28)
This work presents the study of the effects of an RGD disintegrin from Rhinocerophis alternatus (ancient Bothrops alternatus) in key steps of the metastatic cascade. Disintegrins are cysteine-rich peptides, which have ...
Desintegrinas de Bothrops alternatus: biologia molecular, estudos in vitro, in vivo e bioinformática estrutural.
(Universidade Federal de São Carlos, 2005-11-28)
Disintegrins are toxins frequently found in snake venoms. Their biological
effects are due to their binding to cell receptors known as integrins. Aiming to isolate
new disintegrins from Bothrops alternatus snake, a cDNA ...
Otimização da purificação e caracterização adicional de uma desintegrina-RGD recombinante de Bothrops alternatus e seu efeito em células endoteliais humanas (HUVEC).
(Universidade Federal de São Carlos, 2006-11-23)
Disintegrins are snake venom protein, of low molecular weight, rich in cysteines and RGDcontaining peptides that bind specifically to integrins αIIbβ3, α5β1, and αvβ3 expressed on
platelets, ...
Efeitos de uma desintegrina recombinante de Bothrops alternatus, DISBA-01, em células precursoras miogênicas (CPM)
(Universidade Federal de São Carlos, 2009-09-21)
Disintegrins are toxins commonly found in snake venoms whose biological effects occour upon interaction with surface receptors known as integrins. DisBa-01, an RGD disintegrin isolated from a cDNA library made with mRNAs ...
Comparação transcricional dos túbulos de Malpighi e corpo gorduroso de Zophobas morio: função de AMP-CoA ligases nos túbulos e relação com lanternas de Arachnocampa luminosa
(Universidade Federal de São Carlos, 2017-10-27)
The Malpighian tubules in insects play an essential role in osmoregulation, performing transport of ions and fluids during the formation of primary urine, whereas fat body is usually associated with the intermediary ...
Estudos genético-populacionais em Astyanax aff. Scabripinnis da região da Serra da Mantiqueira
(Universidade Federal de São Carlos, 2018-10-19)
Genetic studies of natural populations have long been helping the scientific community and society in general to understand the evolution and conservation of both environments and communities. These studies have helped to ...
Análises Bioinformáticas de Proteínas de Resistência do Tipo Nucleotide Binding Site-Leucine Rich Repeat (NBS-LRR) de Café
(Universidade Federal de São Carlos, 2019-02-15)
The molecular factors involved in the coffee’s resistance to rust and other diseases have not been completely known, but related projects have been developed since the last century. One of the main problems that make ...