• Integração de métodos in silico e in vitro para o planejamento de inibidores da enzima cruzaína 

      Wiggers, Helton José (Universidade Federal de São Carlos, UFSCar, Programa de Pós-Graduação em Química - PPGQ, , 30/06/2011)
      Chagas disease, caused by the flagellate protozoan of the family Trypanosomatidae Trypanosoma cruzi, is endemic in Latin America. The available drugs are ineffective and cause severe side effects. Therefore, it is necessary ...
    • Planejamento de inibidores da cruzaína baseado em fragmentos 

      Fonseca, Emanuella Maria Barreto (Universidade Federal de São Carlos, UFSCar, Programa de Pós-Graduação em Química - PPGQ, , 27/07/2011)
      The Chagas disease, described in 1909 by the Brazilian sanitary physician, scientist and bacteriologist Dr. Carlos Chagas, is caused by the Trypanosomatid parasite Trypanosoma cruzi. Current treatments involve the use of ...
    • Ensaios bioquímicos e celulares para a identificação de novos inibidores de TcGAPDH seletivos à HsGAPDH 

      Soares, Fabyana Aparecida (Universidade Federal de São Carlos, UFSCar, Programa de Pós-Graduação em Química - PPGQ, , 11/08/2011)
      Chagas disease is a tropical neglected illness; nearly 10 million people are infected, in 2008 it was responsible for the deaths of about 10 thousand people. At present, only two medicines (benznidazol and nifurtimox) are ...