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Estudo químico de plantas do gênero Hortia, do fungo Guignardia citricarpa e avaliação de seus potenciais efeitos biológicos
(Universidade Federal de São Carlos, 2011-10-26)
The chemical investigation of plants belonging to the genus Hortia described here aimed at contributing to the chemosystematics of the family Rutaceae as well as to the correct placement of this genus within this family. ...
Integração de métodos in silico e in vitro para o planejamento de inibidores da enzima cruzaína
(Universidade Federal de São Carlos, 2011-06-30)
Chagas disease, caused by the flagellate protozoan of the family Trypanosomatidae Trypanosoma cruzi, is endemic in Latin America. The available drugs are ineffective and cause severe side effects. Therefore, it is necessary ...
Síntese e avaliação da atividade biológica de compostos N-Heterocíclicos
(Universidade Federal de São Carlos, 2011-07-28)
N-heterocyclic compounds have a large number of biochemical and medical applications and an important role in the discovery of new drugs, and many of best sellers, currently in use, contains one or more N-heterocyclic ...
Ressonância magnética nuclear ultrarrápida: implementação, desenvolvimento e aplicações
(Universidade Federal de São Carlos, 2011-11-24)
This work highlights the implementation, development and application of the Ultrafast Nuclear Magnetic Resonance (UFNMR) technique, proposed by Frydman and co-workers. Through this technique, it is possible to perform ...
Estudo da atividade biológica do motivo ECD do domínio tipo-desintegrina da botropasina
(Universidade Federal de São Carlos, 2011-05-10)
Integrins are cell surface receptors that mediate cell adhesion and platelet aggregation, although they do part of important physiological processes in the organism, are also related pathologies such as tumorigenesis, ...
Planejamento de inibidores da cruzaína baseado em fragmentos
(Universidade Federal de São Carlos, 2011-07-27)
The Chagas disease, described in 1909 by the Brazilian sanitary physician, scientist and bacteriologist Dr. Carlos Chagas, is caused by the Trypanosomatid parasite Trypanosoma cruzi. Current treatments involve the use of ...
Ensaios bioquímicos e celulares para a identificação de novos inibidores de TcGAPDH seletivos à HsGAPDH
(Universidade Federal de São Carlos, 2011-08-11)
Chagas disease is a tropical neglected illness; nearly 10 million people are infected, in 2008 it was responsible for the deaths of about 10 thousand people. At present, only two medicines (benznidazol and nifurtimox) are ...
Terpenóides e seu metabolismo em fungos: um estudo de Scleroderma sp. e Xylaria sp.
(Universidade Federal de São Carlos, 2011-08-05)
In the present work, the lanostane triterpenes Lanosta-8,24-diene-3β,23-diol and Lanosta-8,23-diene-3β,25-diol were isolated from the basidiomycete Scleroderma sp., an extremely rich source of triterpenes and not ...