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Clonagem e caracterização das isoformas de luciferases de lanternas e corpo gorduroso do vagalume Aspisoma lineatum (Lampyridae: Cratomorphini): origem estrutural e evolutiva das luciferases pH-sensitivas mais eficientes à partir de ancestrais pH-insensitivas
(Universidade Federal de São Carlos, 2020-10-31)
Firefly luciferases emit yellow-green light with high efficiency at physiological pH. However, under acidic conditions, in the presence of heavy metals or high temperatures, they emit red light. To understand the structural ...
Estudo dos efeitos antiangiogênicos da desintegrina-símile Alternagina-C (ALT-C) em células endoteliais (HUVEC), tendo como alvo a integrina α2β1
(Universidade Federal de São Carlos, 2020-03-04)
Angiogenesis is a crucial process in tumor progression, and it is mainly regulated by the vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. Studies have shown that VEGF/VEGFR2 axis signaling is directly ...
A integrina a2b1 na progressão tumoral mamária: papel no microambiente tumoral e na metástase
(Universidade Federal de São Carlos, 2019-08-23)
The harmonic functioning of cells involves an orchestrated synchronization of signaling that maintains the balance between proliferation and cell death in healthy tissues. Eventually, gene mutations can occur and the ...
Citogenética comparativa em espécies de Hypostomus (Siluriformes, Loricariidae, Hypostominae). Contribuição da fração repetitiva do genoma para a diversidade cromossômica do grupo
(Universidade Federal de São Carlos, 2012-11-14)
Hypostomus is the widest genus of the armored catfishes in South America. This group presents a great diversity in color pattern and morphology, and shows not conservative chromosomal features. Different classes of repetitive ...
Estudos evolutivos em Auchenipteridae (Siluriformes): citogenética, DNA mitocondrial e DNA satélite
(Universidade Federal de São Carlos, 2013-02-04)
The neotropical freshwater fish fauna is the most diverse in the world, with more than 4.000 descrbed spcecies. In Brazil, about 2.500 species of freshwater fishes are considered valid, and the most formallyand a small ...
Efeito do tratamento com hidroxiureia sobre a expressão gênica de ATF4, MSN, PBXIPI e SNCA em pacientes com anemia falciforme e em células K562
(Universidade Federal de São Carlos, 2020-03-06)
Our study aimed to analyze the expression and protein content of four genes (ATF4, MSN, PBXIP1 and SNCA) by qPCR and Western Blotting in individuals with sickle cell anemia treated and not treated with hydroxyurea (HU) in ...
Genética populacional de felinos e as ameaças para Puma concolor: estruturação populacional recente e atropelamentos
(Universidade Federal de São Carlos, 2018-06-25)
Species around the world are increasingly exposed to new threats due to human activities. The main threat is the landscape modification by human activities, resulting in demographic and genetic pattern changes of species ...
Caracterização funcional parcial de dois genes de Xanthomonas citri potencialmente relacionados com a patogenicidade: XAC1006 (malato desidrogenase) e XAC0223 (proteína hipotética conservada)
(Universidade Federal de São Carlos, 2019-02-12)
The bacterium Xanthomonas citri subsp. citri (XAC) is the cause of citrus canker, a disease that affects many species of citric plants, causing drop in productivity and losses to producers. Many proteins have been detected ...