Desenvolvimento de manta flexível altamente bioativa
Souza, Marina Trevelin
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Recently, intensive studies have been conducted with biomaterials aiming their application as synthetic grafts for reparation and maintenance of bones, teeth and cartilage tissues that have been damaged or lost due to trauma or disease. However, only limited groups of materials are biologically acceptable to the human body as substituents or repairing agents of soft and hard tissues. Bioactive glasses have been studied and used as synthetic grafts in clinical cases for about 30 years, and some of them can interact perfectly with body tissues. Nevertheless, their use is still restricted due to their fragility and the limitation of commercially available forms such as powder, granules or rigid scaffolds. Therefore, a research for a process to obtain fibers and meshes is promising, as this new format could expand the spectrum of clinical use of this biomaterial. Thus, this project intended to acquire highly bioactive glass fibers and, therefore, to develop meshes that can be applied both in medical and dental surgical procedures. For that purpose, new bioactive vitreous compositions were studied and developed with the following characteristics: fast interaction with body fluids to promote rapid regeneration process, this property was analyzed in vitro using SBF-K9 solution, and also reduced tendency to devitrify during its processing as fibers, as the crystallization hinders or even prevents one to obtain the fibers, and affect their mechanical strength. Using differential scanning calorimetry analysis (DSC) the compositions more suited to the downdrawing process were selected and from them it was possible to obtain continuous fibers with uniform diameter using the fiber drawing machine located at the Laboratório de Materiais Vítreos (LaMaV - UFSCar).