Flow Chemistry: From assembly to the application

Abstract

Over the centuries, chemical reactions have been carried out in the same way in standardized glassware. On the other hand, continuous flow reactions are gaining interest regularly and demand for the related hardware toolkit is also increasing every day. In this scenario, the current work describes assembly of different continuous flow reaction systems that enable: I. Synthesis of trisubstituted 1,2,3-triazoles using molecular sieve as a solid catalyst; II. Organocatalytic applications of multicomponent reaction-derived prolyl pseudo-peptide catalysts supported on the renewable polymer applied to asymmetric Michael addition; III. Photochemical process for the synthesis of indoles and indolines. Moreover, an instrumental setup configuration was created that combines the advantages of chromatography and online analysis of the reactional parameters.