dc.contributor.author | Mello, Marcos Vinícius Palmeira de | |
dc.contributor.author | Caballero, Ana Belen | |
dc.contributor.author | Herrera-Ramírez, Piedad | |
dc.contributor.author | Costa, Analu Rocha | |
dc.contributor.author | Santana, Savyo Souza | |
dc.contributor.author | Guedes, Guilherme Pereira | |
dc.contributor.author | Caubet, Amparo | |
dc.contributor.author | Batista, Alzir Azevedo | |
dc.contributor.author | Gamez, Patrick | |
dc.contributor.author | Lanznaster, Mauricio | |
dc.date.accessioned | 2024-02-15T16:44:37Z | |
dc.date.available | 2024-02-15T16:44:37Z | |
dc.date.issued | 2023-08-02 | |
dc.identifier | https://doi.org/10.1016/j.jinorgbio.2023.112345 | por |
dc.identifier.citation | MELLO, Marcos Vinícius Palmeira de; CABALLERO, Ana Belen; HERRERA-RAMÍREZ, Piedad; COSTA, Analu Rocha; SANTANA, Savyo Souza; GUEDES, Guilherme Pereira; CAUBET, Amparo; BATISTA, Alzir Azevedo; GAMEZ, Patrick; LANZNASTER, Mauricio. Cobalt(III)-py2en systems as potential carriers of β-ketoester-based ligands. Journal of Inorganic Biochemistry, v. 248, p. 112345, 2023. Disponível em: https://repositorio.ufscar.br/handle/ufscar/19283. | * |
dc.identifier.uri | https://repositorio.ufscar.br/handle/ufscar/19283 | |
dc.description.abstract | Two cobalt(III) complexes containing different β-ketoesters, namely [CoIII(L1)(py2en)](ClO4)2⋅H2O (1) and
[CoIII(L2)(py2en)](ClO4)2 (2) (py2en = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine; L1¡ = methylacetoacetate; L2¡ = ethyl 4-chloroacetoacetate) have been prepared and investigated as prototypes of bioreductive prodrugs. The presence of β-ketoester and py2en ligands in 1 and 2, as well as the perchlorate counterions, was supported by IR spectroscopy and CHN elemental analysis. The composition molecular structure of both complexes was confirmed by NMR spectroscopy and ESI mass spectrometry. Structural information was also obtained for 2 via Xray diffraction analysis. The redox properties indicate that 1 and 2 are suitable for reduction under biological conditions. Investigation of DNA-interacting suggest that 1 and 2 bind DNA via electrostatic forces. Both complexes may be employed as possible platforms for the delivery of biologically active compounds, since their reaction with ascorbic acid in PBS at pH 6.2 and 7.4 at 37◦C results in the release of the β-ketoester ligands upon Co(III)/Co(II) reduction. | por |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | por |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | por |
dc.format.extent | 112345 | por |
dc.language.iso | eng | por |
dc.publisher | Universidade Federal de São Carlos | por |
dc.relation.ispartof | Journal of Inorganic Biochemistry | por |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Brazil | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/br/ | * |
dc.subject | Cobalt(III) complexes | eng |
dc.subject | b-Ketoester | por |
dc.subject | Prodrugs | eng |
dc.subject | Hypoxia-activated drug delivery | eng |
dc.subject | Anticancer drugs | eng |
dc.subject | DNA binding | eng |
dc.title | Cobalt(III)-py2en systems as potential carriers of β-ketoester-based ligands | eng |
dc.type | Artigo | por |
dc.publisher.initials | UFSCar | por |
dc.subject.cnpq | CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA::CAMPOS DE COORDENACAO | por |
dc.subject.cnpq | CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA::QUIMICA BIO-INORGANICA | por |
dc.subject.cnpq | CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA | por |
dc.description.sponsorshipId | Processo nº 2021/01787-0, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | por |
dc.description.sponsorshipId | Processo nº 88881.187405/2018-01, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | por |
dc.publisher.address | Câmpus São Carlos | por |
dc.contributor.authorlattes | http://lattes.cnpq.br/8894654634441028 | por |
dc.publisher.department | Centro de Ciências Exatas e de Tecnologia - CCET | por |
dc.publisher.department | Departamento de Química - DQ | por |
dc.publisher.department | Programa de Pós-Graduação em Química - PPGQ | por |
dc.citation.volume | 248 | por |
dc.contributor.authororcid | https://orcid.org/0000-0003-2550-5315 | por |