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Busca por inibidores de catepsinas em plantas do cerrado paulista e avaliação da proteólise tumoral in vitro
(Universidade Federal de São Carlos, 2015-03-27)
The aim of this work is search for cysteine proteases inhibitors using a bioactivity-guided assay. We have selected different plants for the initial screening. Among all evaluated extracts, the ones obtained from Myrcia ...
Ressonância magnética nuclear ultrarrápida: implementação, desenvolvimento e aplicações
(Universidade Federal de São Carlos, 2011-11-24)
This work highlights the implementation, development and application of the Ultrafast Nuclear Magnetic Resonance (UFNMR) technique, proposed by Frydman and co-workers. Through this technique, it is possible to perform ...
Integração de métodos in silico e in vitro para o planejamento de inibidores da enzima cruzaína
(Universidade Federal de São Carlos, 2011-06-30)
Chagas disease, caused by the flagellate protozoan of the family Trypanosomatidae Trypanosoma cruzi, is endemic in Latin America. The available drugs are ineffective and cause severe side effects. Therefore, it is necessary ...
Reações multicomponentes de Diels-Alder com parabenzoquinonas : intermediários para Sesquiterpenos Eudesmanos
(Universidade Federal de São Carlos, 2010-09-20)
In the first part of this thesis we describe the study of the oxidation of phenols to p-benzoquinones. The metal complexes used as catalysts in this study are: [CoII(salen)], [CoII(dmsalen)], [CoII(salpn)], [CoII(dmsalpn)], ...
Síntese e avaliação da atividade biológica de compostos N-Heterocíclicos
(Universidade Federal de São Carlos, 2011-07-28)
N-heterocyclic compounds have a large number of biochemical and medical applications and an important role in the discovery of new drugs, and many of best sellers, currently in use, contains one or more N-heterocyclic ...
Estudo de metabólitos secundários de Ruta graveolens como inibidores da fotossíntese
(Universidade Federal de São Carlos, 2012-12-09)
In this work were isolated eighteen secondary metabolites from Ruta graveolens (Rutaceae), eleven alkaloids (five akridonic, five quinolinics and one quinolonic) and seven furanocoumarins. Thirteen compounds had their ...
Estudo químico em patógenos e vetores de doenças de citros: Xylella fastidiosa e Diaphorina citri
(Universidade Federal de São Carlos, 2011-07-04)
CHEMICAL STUDY OF PATHOGENS AND VECTORS DISEASE OF CITRUS: Xylella fastidiosa & Diaphorina citri. Historically the national citriculture suffered great changes because of phytosanitary problems, and nowadays among the main ...
Estudo químico e biológico de micro-organismos endofíticos associados às frutas banana, pêra e goiaba
(Universidade Federal de São Carlos, 2010-03-05)
Studies about interaction between microorganisms and plants are focused mainly in the vegetal tissues like roots, steam and leaves. Fruits are a right target for microorganism attacks. Nevertheless, endophytic microorganisms ...
Ensaios bioquímicos e celulares para a identificação de novos inibidores de TcGAPDH seletivos à HsGAPDH
(Universidade Federal de São Carlos, 2011-08-11)
Chagas disease is a tropical neglected illness; nearly 10 million people are infected, in 2008 it was responsible for the deaths of about 10 thousand people. At present, only two medicines (benznidazol and nifurtimox) are ...
Metátese de fechamento de anel: espiro-anelação estereosseletiva / Reações multicomponentes de Diels-Alder na síntese de compostos tricíclicos
(Universidade Federal de São Carlos, 2011-02-22)
In this work, a study of different synthetic ways was made in order to obtain spiro compounds starting from R-(-)-carvone, getting to the formation of cycloheptenone as an intermediate, which undergoes two consecutives ...