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Estudo da atividade biológica do motivo ECD do domínio tipo-desintegrina da botropasina
(Universidade Federal de São Carlos, 2011-05-10)
Integrins are cell surface receptors that mediate cell adhesion and platelet aggregation, although they do part of important physiological processes in the organism, are also related pathologies such as tumorigenesis, ...
Ensaios bioquímicos e celulares para a identificação de novos inibidores de TcGAPDH seletivos à HsGAPDH
(Universidade Federal de São Carlos, 2011-08-11)
Chagas disease is a tropical neglected illness; nearly 10 million people are infected, in 2008 it was responsible for the deaths of about 10 thousand people. At present, only two medicines (benznidazol and nifurtimox) are ...
Metátese de fechamento de anel: espiro-anelação estereosseletiva / Reações multicomponentes de Diels-Alder na síntese de compostos tricíclicos
(Universidade Federal de São Carlos, 2011-02-22)
In this work, a study of different synthetic ways was made in order to obtain spiro compounds starting from R-(-)-carvone, getting to the formation of cycloheptenone as an intermediate, which undergoes two consecutives ...
Planejamento de inibidores da cruzaína baseado em fragmentos
(Universidade Federal de São Carlos, 2011-07-27)
The Chagas disease, described in 1909 by the Brazilian sanitary physician, scientist and bacteriologist Dr. Carlos Chagas, is caused by the Trypanosomatid parasite Trypanosoma cruzi. Current treatments involve the use of ...
Emprego da organocatálise como uma ferramenta da química verde em reações de adição conjugada : estudos visando a síntese de anéis indólicos
(Universidade Federal de São Carlos, 2012-03-30)
Organocatalysis has emerged as a powerful synthetic paradigm and has accelerated the development of new methods to make diverse chiral molecules. In addition, the small chiral organic molecules used to accelerate asymmetric ...
Precessão Livre de Onda Contínua (CWFP) como ferramenta para supressão do sinal de solvente em RMN de alta resolução
(Universidade Federal de São Carlos, 2011-08-01)
The application of Continuous Wave Free Precession (CWFP) method for solvent suppression in high resolution NMR spectroscopy is reported. The applied methodology was based in the use of conventional pulse sequence that use ...
Atividade inseticida de espécies de trichilia frente à lagarta-do-cartucho do milho spodoptera frugiperda
(Universidade Federal de São Carlos, 2008-07-18)
This work presents the phytochemical study and biological assays carried out with organic extracts of fruits and seeds
from Trichilia claussenii, T. elegans and inflorescence from T. catigua against S. frugiperda. Among ...
Estudo químico e biológico de micro-organismos endofíticos associados às frutas banana, pêra e goiaba
(Universidade Federal de São Carlos, 2010-03-05)
Studies about interaction between microorganisms and plants are focused mainly in the vegetal tissues like roots, steam and leaves. Fruits are a right target for microorganism attacks. Nevertheless, endophytic microorganisms ...
Estudo fitoquímico de Rauia sp e atividades sobre formigas cortadeiras e sobre a lagarta-do-cartucho do milho
(Universidade Federal de São Carlos, 2009-09-11)
The control of agriculture plague is relevant to Brazil that has large crop area. The control, by natural product, generally low toxic to humans and to animals and specific to target plague, is recommended. This work ...
Estudo do perfil químico de Cyperus rotundus e avaliação do seu potencial de absorção de metais
(Universidade Federal de São Carlos, 2016-07-27)
The following work describes the comparative study of the variation between chemical profiles of plants of the Cyperus rotundus species – where one was collected at Vale S.A.’s dumping ground in Canaã dos Carajás city, ...