Incorporação em lipossomos da aloína e imobilização em filmes nanoestruturados para aplicação em liberação modificada de fármacos

Abstract

Currently, thanks to the high due technological development, a new class of systems has been explored for drug delivery systems, or controlled release of drugs. These systems have great importance as a rare drug in an aqueous solution or in the conventional way can achieve the target concentrations appropriate to achieve the desired therapeutic efficacy, for this reason, in recent years a new pharmacological concept was developed through the preparation of biologically active systems with the use of molecular aggregates. Among the delivery systems most studied, we highlight the liposomes, micelles, polymeric nanoparticles, dendrimers and carbon nanotubes. In this work we immobilized Aloin (barbaloin), component present in Aloe vera, which has healing activity, in nanostructured films, using the technique of self-assembly layer by layer ( LbL). To obtain the ultrathin films for the process Layer-by-Layer, Aloin (barbaloin) was incorporated into dipalmitoyl phosphatidyl glycerol (DPPG) liposomes and self-assembled with polyelectrolytes to development of a drug controlled release system of the adhesive type (patches). The film growth and its ability to release the Aloin were monitored using UV-visible and fluorescence spectroscopy. The films showed linear growth, indicating that the same amount of material was absorbed in each deposition step. Aloin release from the LbL films made with DPPG liposomes showed constant for 12 hours. This possibility of release through a long time course is promising for medical applications using patches.