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    Kant, Bakhtin, Câmara Jr.: problemas epistêmicos na linguística brasileira
    (Universidade Federal de São Carlos, 2026-07-16)
    Paiva, Moisés Almada Melo de
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    Maciel, Lucas Vinicio de Carvalho
    ;
    http://lattes.cnpq.br/8779101339709622
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    https://orcid.org/0000-0002-0959-4285
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    http://lattes.cnpq.br/3561189387825943
    This Final Coursework explores the relationship between linguistics and philosophy, focusing on the works of Immanuel Kant, Mikhail Bakhtin, and Mattoso Câmara Jr., through a comparative study centered on the philosophy of language. The core issue under debate is the persistence of historiographical stereotypes in Brazilian academia (such as viewing Bakhtin as a “historical materialist,” Kant as an “idealist,” and Câmara Jr. as a “structuralist”), which limit a factual understanding of their contributions, as noted in prior studies. The general objective is to demonstrate whether a comparative approach to the works Critique of Practical Reason (Kant, 2016[1788]), Principles of General Linguistics (Câmara Jr.), and Toward a Philosophy of the Act (Bakhtin, 2010[1984]) fosters a more precise understanding of their ideas. As specific objectives, it proposes: a) to investigate interpretations that lead to misunderstandings of their works; b) to identify concepts that facilitate approximation between the authors; c) to compare the role of theoretical presuppositions in this connection; d) to assess whether this effort results in a more faithful interpretation. The research is classified as comparative, confronting the selected works to challenge current ways of understanding them; it is also historical, documentary, and bibliographic, reconstructing their intersections and reviewing prior studies. Theoretically, it draws on Fricker (2023) regarding epistemic injustice applied to Brazilian linguistics. The analyses reveal deep connections between the works, questioning stereotypes and identifying concepts such as subject, act, and event that enable a more faithful reinterpretation, especially of Bakhtin’s profile, distinct from the predominant view.
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    Efeitos do bisfenol-a na capacidade fotossintética e no crescimento de Egeria densa
    (Universidade Federal de São Carlos, 2026-10-22)
    Praes, Lavínia Carolini Rios
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    Cunha-Santino , Marcela Bianchessi da
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    http://lattes.cnpq.br/2356641063223397
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    https://orcid.org/0000-0001-6048-0745
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    http://lattes.cnpq.br/3903264919955823
    Bisphenol A (BPA) is an emerging contaminant widely used in the plastics industry; its persistent presence in inland water bodies poses a potential threat to aquatic biota. This study investigated the effects of three BPA concentrations (5 mg L⁻¹ [T1], 15 mg L⁻¹ [T2], and 25 mg L⁻¹ [T3], alongside a control [TC]) on the net photosynthetic rates and growth kinetic parameters of the submerged aquatic macrophyte Egeria densa under controlled laboratory conditions (27 °C and a 12-h photoperiod). Median net photosynthetic rates were 1.75 (TC), 1.00 (T1), 1.25 (T2), and 1.35 mg O₂ g⁻¹ DW h⁻¹ (T3). Although photosynthetic activity decreased, treatment differences were not statistically significant (p > 0.05). In contrast, growth kinetic parameters were highly sensitive to the pollutant, with significant differences (p < 0.05) between the control and the higher-concentration treatments (T2 and T3). The growth coefficient (µ) decreased progressively with increasing contaminant levels: 0.14 day⁻¹ in the TC (doubling time, td = 5 days), 0.07 day⁻¹ in T1, 0.04 day⁻¹ in T2, and 0.02 day⁻¹ in T3; this demonstrates that the control value was seven times higher than that of the treatment with 25 mg BPA L⁻¹. Each 1 mg L⁻¹ increase in BPA reduced the plant growth coefficient by approximately 9%. The half-life of the compound in the experimental media ranged from 6.6 to 8.5 weeks. The results suggest that the growth coefficient of E. densa is a more adequate biometric indicator of BPA contamination than net photosynthetic rate, highlighting the importance of integrated approaches for assessing the toxicity of micropollutants in macrophytes.
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    Rastreio de situações de trauma entre os profissionais da Atenção Primária à Saúde, por meio do aplicativo APP Mental
    (Universidade Federal de São Carlos, 2026-10-26)
    Ferreira, Vitória Caroline dos Santos
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    Martini, Larissa Campagna
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    http://lattes.cnpq.br/8969823407559809
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    https://orcid.org/0000-0002-4766-0634
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    http://lattes.cnpq.br/4392869893747920
    Health professionals work in unpredictable contexts and are exposed to stressful events with traumatic potential, which causes mental health damage, including post-traumatic stress disorder (PTSD). This study evaluates the feasibility of the APP Mental application for the prevention and screening of PTSD symptoms among health professionals, using the Posttraumatic Stress Disorder Checklist (PCL-5). The research adopts a quantitative, cross-sectional design, with approval from the institutional research ethics committee. The sample comprises individuals over 18 years of age, formally employed by the municipal health department and assigned to Primary Health Care services, who interact with the application for 12 weeks. The application administers a sociodemographic questionnaire and asks about experiences of trauma throughout life, and it sends the PCL-5 to users who report trauma, with a cutoff score of 31 or higher. The analysis uses descriptive statistics in RStudio software. The theoretical framework relies on the DSM-5 diagnostic criteria and on studies that associate occupational exposure to traumatic events with psychological distress among health workers. In the partial results, the sample comprises 28 people, mostly women (96.4%), with a mean age of 42 years. Among the 12 PCL-5 respondents, half (50%) score 31 or higher, which indicates greater symptom severity. The study concludes that the preliminary data reinforce the importance of mental health promotion, prevention, and care actions for health workers and indicate the need to develop educational materials on trauma and coping with stress.
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    Investigação dos sítios de interação entre as cadeias peptídicas do beta-amiloide usando as propriedades fotoquímicas e fotofísicas do complexo luminescente cis-[Ru(phen)2(Aepy)2]2+
    (Universidade Federal de São Carlos, 2026-09-30)
    Silva, Ana Carla Candido da
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    Carlos, Rose Maria
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    http://lattes.cnpq.br/1589143355309943
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    https://orcid.org/0000-0002-0277-9789
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    http://lattes.cnpq.br/7616380561592904
    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with the aggregation of amyloid-β peptide (Aβ) into species ranging from soluble oligomers to amyloid fibrils and plaques. Understanding the molecular interactions involved in this process is important for identifying peptide regions associated with aggregate formation and stabilization. In this context, Ru(II) polypyridyl complexes exhibit photophysical and photochemical properties that make them useful molecular tools for investigating amyloid aggregation. In this work, the luminescent RuAepy complex was investigated with emphasis on its interaction with Aβ and the identification of peptide regions involved in this process. The complex was synthesized and characterized by spectroscopic and spectrometric techniques, and its photophysical and photochemical properties were evaluated in solution. Its interaction with Aβ was investigated using Aβ₁₋₄₀, Aβ₁₋₄2 and peptide fragments by luminescence spectroscopy and 1H nuclear magnetic resonance (1H NMR). Luminescence studies revealed changes in the intrinsic emission of Tyr10 in the presence of RuAepy, indicating modifications in its local microenvironment. The in situ and ex situ experiments showed that RuAepy affects Aβ species and modifies its aggregation behavior. Studies using peptide fragments, combined with 1H NMR analyses, indicated the involvement of the N-terminal region, particularly His6, in the interaction with the complex. Overall, the results demonstrate that RuAepy interacts with Aβ and modifies its aggregation process, supporting the use of Ru(II) polypyridyl complexes as molecular tools for investigating the interactions involved in amyloid aggregate formation.
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    Funcionalidade e qualidade de vida na gestação: um estudo transversal
    (Universidade Federal de São Carlos, 2025-06-27)
    Archanjo, Bianca de Lima
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    Zanoni, Mariana Paleari
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    Silva, Clara Maria de Araujo
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    Carrer, Helen Cristina Nogueira
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    http://lattes.cnpq.br/9985037319198420
    Pregnancy is a physiological process marked by physical, emotional, and social changes that can affect a woman’s functioning and quality of life. Changes throughout the trimesters impact daily activities and the perception of well-being. Assessing these aspects allows for a better understanding of the needs of pregnant women and helps guide care that is more appropriate for each stage of pregnancy. Objective: To describe the functional status and quality of life of Brazilian pregnant women in different trimesters. Method: This is an observational, cross-sectional study (CAAE:78496324.3.0000.5504) that included Brazilian pregnant women aged ≥ 18 years receiving prenatal care. A questionnaire was used to collect personal and sociodemographic data, in addition to two other questionnaires: the World Health Organization Quality of Life BREF and the World Health Organization Disability Assessment Schedule 2.0. The participants’ demographic data were analyzed descriptively. Analyses of the scores for functional status and quality of life, as well as comparisons between trimesters, were performed using Welch’s ANOVA with a Games-Howell post hoc test (p < 0.05). Results: A total of 110 pregnant women participated: 28.2% (31) were in the first trimester with a mean age of 32.9 ±4.3 years, 30.9% (34) were in the second trimester with a mean age of 31.9 ±5.3 years, and 40.9% (45) were in the third trimester with a mean age of 30.2 ±5.38 years. The mean parity was 0.77 ± 0.9, 0.8 ± 1.1, and 0.86 ± 0.9, respectively, across the trimesters. There was a progressive decline in functional status (WHODAS: 18.2 in the first trimester, 22.5 in the second, and 25.9 in the third; p < 0.001). Quality of life declined in the physical (p=0.004), social relationships (p=0.020), and environment (p<0.001) domains, particularly in the third trimester. The psychological domain showed no significant difference. Discussion: The results revealed a progressive decline in functionality and quality of life among pregnant women, especially in the third trimester. The physical, social relationships, and environment domains were the most affected, while the psychological domain remained stable. These findings reinforce the need to address the impact of pregnancy-related changes on women’s overall health. Conclusion: Functionality and quality of life varied throughout pregnancy, especially in the third trimester, influencing mobility and physical performance. Social relationships and the environment were shown to be impacted during pregnancy, whereas the psychological domain did not differ between the groups.