Repositório UFSCar

O Repositório Institucional da UFSCar (RI UFSCar) é um sistema de informação que visa armazenar, preservar, organizar e disseminar amplamente a produção intelectual dos diversos setores e segmentos da comunidade da UFSCar, provendo o acesso aberto à informação produzida na instituição e registrada como científica, tecnológica, didática, artístico-cultural e técnico-administrativa.

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Nanossistemas poliméricos para tratamento do câncer de pulmão: o efeito corona proteica
(Universidade Federal de São Carlos, 2025-12-05) Saladine, Maria Eduarda da Silva; Leite, Ana Elisa Tognoli; http://lattes.cnpq.br/3170931739485037; https://orcid.org/0000-0002-4300-9414; Camargo, Emerson Rodrigues de; http://lattes.cnpq.br/7720754304065239; https://orcid.org/0000-0003-2893-5353; http://lattes.cnpq.br/7009789390549305; https://orcid.org/0000-0002-4489-8284
Lung cancer is the leading cause of cancer mortality, with cisplatin being widely used in its treatment despite its low tumor specificity and high systemic toxicity. PLGA polymeric nanoparticles emerge as an alternative to improve drug delivery; however, in biological media, they interact with proteins, forming the protein corona, which can alter their properties and biological effects. This study evaluated the influence of surface charge and incubation time on protein corona formation, as well as its cytotoxic effects on A549 cells. PLGA nanoparticles, with and without chitosan coating, were incubated in a medium containing fetal bovine serum and characterized regarding size, zeta potential, protein concentration, morphology, and chemical structure. The nanoparticles exhibited spherical morphology, an average size of 75 nm, a zeta potential of –18 mV, and an encapsulation efficiency of 28%. The formation of the protein corona was evidenced by a size increase of approximately 30 nm and a change in surface charge, with higher protein adsorption observed in positively charged nanoparticles and greater protein interaction after 1 h of incubation. The presence of the protein corona resulted in higher cell viability compared to corona-free nanoparticles and free cisplatin, although additional release and internalization studies are required to clarify the lower cytotoxicity observed. The results highlight the importance of the protein corona in modulating the biological interactions of PLGA nanoparticles and in developing safer and more effective nanostructured systems for lung cancer treatment
Caracterização e aplicação da lignina da palha de milho como coagulante e auxiliar de coagulação orgânico na remoção da turbidez de água
(Universidade Federal de São Carlos, 2026-06-16) Diniz, Joice Pereira; Gonzalez, Beatriz Cruz; http://lattes.cnpq.br/4777395189579793; Matos, Andreia Pereira; http://lattes.cnpq.br/6155202940087696; http://lattes.cnpq.br/8682457468741473
Water treatment plants (WTPs) are critical components of a municipality’s water supply system; they consist of the operational steps involved in treating surface water to ensure its quality and potability. One of these essential steps is coagulation, in which aluminum sulfate is commonly used. This coagulant presents both operational advantages and disadvantages for WTPs, raising the possibility of using plant-based polymers, such as lignin from corn stover. The objective of this study was to extract, modify, and apply lignin from corn stover as a coagulant and coagulation aid for turbidity removal. Extraction was performed using the soda pulping method, followed by chemical modification through oxidation with hydrogen peroxide. To validate the effects of the modification, the lignin was characterized using Ultraviolet-Visible Spectroscopy (UV-Vis), Nuclear Magnetic Resonance (¹H NMR), Thermogravimetric Analysis (TGA), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Energy-Dispersive X-ray Spectroscopy (EDS). Synthetic water was prepared, and batch Jar Tests were conducted using aluminum sulfate and lignin as primary coagulants to determine the optimal dosages for removal; subsequently, aluminum sulfate and lignin were applied as coagulation aids using the analysis of variance (ANOVA) methodology. The optimal dosages of aluminum sulfate were 80 mg. L⁻¹ for a settling time of 10 minutes and 50 mg. L⁻¹ for a settling time of 30 minutes; the lignins had no significant effect on turbidity removal, and their role as a coagulation aid was also ineffective, as confirmed by ANOVA with hypothesis testing (p-value > 0.05). Therefore, it was concluded that lignin was not capable of removing turbidity from the synthetic water within the predetermined times in the Jar Test. It is recommended that future studies use a turbidity level close to 100 NTU and evaluate the effects of lignin by altering the operational conditions of the Jar Test, such as pH.
Práticas de disciplinamento e controle dos corpos dos bebês na creche
(Universidade Federal de São Carlos, 2026-07-08) Proença, Larissa Quédema Gomes de; Lombardi, Lucia Maria Salgado dos Santos; http://lattes.cnpq.br/5697508831302188; https://orcid.org/0000-0001-6978-864X; https://lattes.cnpq.br/4345406232245420; https://orcid.org/0009-0007-4016-2783
This study investigates practices regarding the disciplining and control of babies' bodies within the daily routine of daycare centers. The research aims to understand how practices controlling babies' bodies manifest in the institutional daily routine and to reflect on how early childhood educators can move beyond forms of controlling and disciplining children's bodies, thereby promoting pedagogical practices that are more sensitive, respectful, and committed to babies' rights. The central research question is: how do practices controlling babies' bodies occur in the daily life of daycare centers, and how can early childhood teaching overcome logics of disciplining to foster pedagogical relationships that respect babies' forms of expression? Methodologically, this is a qualitative study of a bibliographic nature (Malheiros, 2011), combined with narrative research on lived experiences (Lima, C. Geraldi, & J. Geraldi, 2015); it also draws on field journal entries produced while the author worked as an Education Assistant at a municipal Early Childhood Education Center in Sorocaba (Proença, 2022). The study is structured around four reflective movements: the methodological approach; a theoretical discussion on early childhood, babies in daycare, and body disciplining, engaging primarily with Michel Foucault and researchers in the Sociology of Childhood and Early Childhood Education; an analysis of three pedagogical scenarios involving play, sleep, and feeding times; and, finally, the concluding remarks. The reflections reveal that frequently naturalized daily practices can generate forms of control over babies' bodies and highlight the need to strengthen a teaching practice grounded in sensitive listening and respect for the rhythms, bodily expressions, and rights of young children.
Mapeamento das práticas integrativas na rede de atenção à saúde: uma pesquisa-ação
(Universidade Federal de São Carlos, 2026-02-25) Santana, Roseléia Maia; Sousa, Leandra Andréia de; http://lattes.cnpq.br/7156410096583566; https://orcid.org/0000-0002-7147-935X; http://lattes.cnpq.br/0787910014547359; Sousa, Leandra Andréia de; Fumincelli, Laís; Silveira, Ana Paula; http://lattes.cnpq.br/7156410096583566; http://lattes.cnpq.br/9372589851606243; http://lattes.cnpq.br/6640516503556080; https://orcid.org/0000-0002-7147-935X; https://orcid.org/0000-0001-9895-8214; https://orcid.org/0000-0002-6761-9807
According to the World Health Organization (WHO), the global progress of Traditional, Complementary and Integrative Medicine (TCIM) has received a significant boost in the last decade, and its inclusion in public systems is recommended worldwide. In Brazil, known as Integrative and Complementary Health Practices (PICS), these approaches have been found in the Unified Health System (SUS) since the 1980s and have had a national policy since 2006. However, their provision and organization within the SUS Health Care Network (RAS) remains a challenge. This research addresses the following questions: Which PICS are offered in the RAS of the municipality of Taquaritinga? By which professionals? In which health services of the RAS are PICS offered? How and where are these practices recorded, including in information systems? How is the RAS organized for the provision of PICS, and how can the RAS be organized for this provision? Is there a referral flow for PICS services? In light of these questions, this study has the general objective of mapping the Health Care Network regarding the provision of Integrative and Complementary Health Practices in the municipality of Taquaritinga, from the perspective of key agents. This is a qualitative study conducted through action research in the RAS of the municipality of Taquaritinga, in the interior of the state of São Paulo. Participants included: health professionals from services offering Integrative and PICS in the RAS, users of the Brazilian Unified Health System (SUS) who utilize these respective services, and professionals from the SUS management at the municipal level. Data collection strategies included questionnaires and workshops. The data produced were analyzed using the dialectical process recommended by Dick (2008) for data analysis in action research. In mapping the provision of Integrative and Complementary Practices within the Health Care Network, six integrative practices were identified: Circular Dance, Meditation, Reiki, Aromatherapy, Auriculotherapy, and Phytotherapy. These practices are offered in five health services, two in Primary Health Care (APS) — specifically in two Family Health Strategies — and three in Secondary Care, including the Psychosocial Care Center (adult and child) and the Medical Specialties Outpatient Clinic. The results revealed a lack of knowledge among professionals regarding the mechanisms for registering PICS, as well as the use of a third-party system without integration with the Ministry of Health. The non-use of the Electronic Citizen's Record (PEC) compromises the monitoring, evaluation, financing, and production of reliable data on PICS in the municipal SUS. Furthermore, the scarcity of financial and material resources, coupled with the absence of a municipal policy, constitutes an obstacle to the implementation of these practices. As a result of the study, a patient care flowchart was collectively developed, which facilitated the expansion of the provision of Integrative and Complementary Practices in other primary health care services. The mapping, combined with the collective construction of the patient care flowchart as an organizational strategy, promoted information sharing among services, improved user reception, and contributed to the incorporation of the Patient Care System (PEC) in the scheduling and registration of PICS. These results were made possible by the participants' engagement throughout the action research. It is noteworthy that these advances were enabled by the collective commitment of the study participants—healthcare professionals, management staff, and users—to PICS and, above all, to the consolidation of the SUS.
Monstros e violência política de gênero: Dilma Rousseff nas capas das revistas impressas brasileiras (2010-2016)
(Universidade Federal de São Carlos, 2026-02-24) Machado, Ariane Cristina; Gonçalves, Viviane; http://lattes.cnpq.br/5225839211648044; https://orcid.org/0000-0002-6819-8995; Oliveira da Silva, Gleidylucy; http://lattes.cnpq.br/1871892858720738; https://orcid.org/0000-0002-2556-8730; http://lattes.cnpq.br/8583560682825727; Kerbauy, Maria Teresa Miceli; Chagas, Viktor Henrique Carneiro de Souza; http://lattes.cnpq.br/4762029784021248; http://lattes.cnpq.br/5832049847796420
This dissertation examines how President Dilma Rousseff (Workers' Party – PT) was framed on the covers of Brazil's leading print magazines—Veja, Época, and IstoÉ—between 2010 and 2016 through the analytical lenses of political monstrosity and gender-based political violence. Drawing on framing theory and scholarship on monstrosity as a social and political phenomenon, the study investigates how visual and textual elements were mobilized to delegitimize the political authority of a woman occupying the highest office in the Executive Branch. Methodologically, the research employs framing analysis based on the content analysis of images, using human coding and the MAXQDA software, with interpretative packages identified on magazine covers as the unit of analysis. The findings indicate that Dilma Rousseff was recurrently framed through representations associated with abnormality, inadequacy, and the transgression of gender expectations, particularly during periods of political crisis. These frames function as symbolic mechanisms of correction, articulating political monstrosity and gender-based political violence. By highlighting these dynamics, the dissertation contributes to the field of Political Communication by incorporating a gender perspective into the critique of political journalism and advancing the understanding of the symbolic processes through which women in politics are delegitimized.