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Biomarcadores sanguíneos para a doença de Alzheimer : avaliação da expressão gênica da ADAM10 e de micro- RNAs
(Universidade Federal de São Carlos, 2016-03-11)
ADAM10 is an-secretase that cleaves APP in the non-amyloidogenic pathway, thereby inhibiting -amyloid peptide (A ) production in Alzheimer´s disease (AD). Studies have shown decreased ADAM10 platelet levels in AD patients ...
Treinamento resistido e reposição hormonal aumentam a atividade das metaloproteinases-2 e a qualidade de osso de ratas ovariectomizadas
(Universidade Federal de São Carlos, 2016-09-16)
Purpose: The aim of the present study was to investigate the influence of resistance training (RT) and hormone replacement (HR) on MMP-2 activity, biomechanical and physical properties bone of ovariectomized (OVX) rats. ...
Remodelamento da matriz extracelular e respostas cardíacas funcionais em ratos idosos submetidos a treinamento resistido
(Universidade Federal de São Carlos, 2016-03-04)
INTRODUCTION: It is well documented that aging causes morphological and functional alterations in the heart. Cardiac ECM remodeling is one event of structural changes in left ventricle (LV), which is modulated by MMPs/TIMPs ...
Investigação do tratamento com N-acetilcisteína nos comportamentos relacionados à ansiedade durante a síndrome de abstinência do etanol e na resposta cardiovascular induzida pelo estresse em ratos
(Universidade Federal de São Carlos, 2019-02-08)
N-acetylcysteine (NAC) for decades, has been shown to have beneficial effects for the treatment of some diseases. Recently, based on central glutamatergic neurotransmission, psychiatric disorders and the stress response ...
ADAM10 como biomarcadora de Transtorno Neurocognitivo Leve
(Universidade Federal de São Carlos, 2020-09-28)
Mild cognitive impairment (MCI), in the absence of dementia, and associated with physical frailty gave rise to the new concept called cognitive frailty. This new concept has also been considered as a subtype of frailty. ...
Papel de um derivado semissintético do [6]-gingerol (SSi6) na morte celular e efeitos antimetastáticos no câncer de mama triplo negativo: estudos in vitro e in vivo
(Universidade Federal de São Carlos, 2021-10-01)
Nowadays, the development of new drugs/compounds to combat breast cancer is one of the main challenges of this research area. Among the different subtypes of this disease, triple negative breast cancer (TNBC) is considered ...
O efeito do exercício físico por meio de intervenção presencial e on-line na composição corporal, parâmetros antropométricos e nos marcadores inflamatórios em mulheres previamente sedentárias
(Universidade Federal de São Carlos, 2021-10-25)
The growing number of people suffering from overweight and obesity increases the demand for
the development of intervention models for lifestyle adjustments based on the regulation of
energy balance and adipose tissue ...
Mecanismos de hipertrofia muscular induzida pelo treinamento de força: análise de marcadores de proteólise, remodelamento de matriz extracelular e adição de mionúcleos mediada por células satélite
(Universidade Federal de São Carlos, 2024-03-21)
The increase in muscle mass (i.e., muscle hypertrophy) promoted by resistance training (RT) results from the activation and coordination of various molecular mechanisms. Some of them have been widely examined, such as ...