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Investigação do tratamento com N-acetilcisteína nos comportamentos relacionados à ansiedade durante a síndrome de abstinência do etanol e na resposta cardiovascular induzida pelo estresse em ratos
(Universidade Federal de São Carlos, 2019-02-08)
N-acetylcysteine (NAC) for decades, has been shown to have beneficial effects for the treatment of some diseases. Recently, based on central glutamatergic neurotransmission, psychiatric disorders and the stress response ...
Análise etofarmacológica do labirinto em cruz elevado aberto para avaliar comportamentos defensivos e a antinocicepção induzida pelo medo em camundongos
(Universidade Federal de São Carlos, 2013-04-12)
Exposure of rodents to an open elevated plus-maze (oEPM) elicits antinociception and increases plasma corticosterone levels. However, no studies have yet assessed the defensive behaviour repertoire of animals in this ...
Efeitos da alimentação e digestão na contratilidade miocárdica de pítons (Python molurus)
(Universidade Federal de São Carlos, 2013-02-28)
Despite all the knowledge about the excitation-contraction coupling (E-C) in mammals, there are still large gaps in the knowledge of the cardiac myocytes physiology in other vertebrates. Thus, the study of groups underexplored ...
Remodelamento da matriz extracelular e respostas cardíacas funcionais em ratos idosos submetidos a treinamento resistido
(Universidade Federal de São Carlos, 2016-03-04)
INTRODUCTION: It is well documented that aging causes morphological and functional alterations in the heart. Cardiac ECM remodeling is one event of structural changes in left ventricle (LV), which is modulated by MMPs/TIMPs ...
Treinamento resistido e reposição hormonal aumentam a atividade das metaloproteinases-2 e a qualidade de osso de ratas ovariectomizadas
(Universidade Federal de São Carlos, 2016-09-16)
Purpose: The aim of the present study was to investigate the influence of resistance training (RT) and hormone replacement (HR) on MMP-2 activity, biomechanical and physical properties bone of ovariectomized (OVX) rats. ...
Modulação dos receptores 5-HT1A e 5-HT2C DO complexo amigdalóide sobre os efeitos da fluoxetina na antinocicepção induzida pelo confinamento de camundongos aos braços do labirinto em cruz elevado
(Universidade Federal de São Carlos, 2016-03-23)
Previous studies have implicated the 5HT1A and 5HT2C serotonin receptors subtypes located within the amygdala in the modulation of defensive behaviors in rodents exposed to the elevated plus-maze (EPM). Further studies ...
Biomarcadores sanguíneos para a doença de Alzheimer : avaliação da expressão gênica da ADAM10 e de micro- RNAs
(Universidade Federal de São Carlos, 2016-03-11)
ADAM10 is an-secretase that cleaves APP in the non-amyloidogenic pathway, thereby inhibiting -amyloid peptide (A ) production in Alzheimer´s disease (AD). Studies have shown decreased ADAM10 platelet levels in AD patients ...
Envolvimento do receptor de angiotensina II tipo 1 nas alterações cardiovasculares induzidas pelo estresse crônico : comparação entre estressores homotípicos e heterotípicos
(Universidade Federal de São Carlos, 2016-03-31)
Emotional stress has been recognized as a risk factor for cardiovascular diseases. Nevertheless, the mechanisms involved in the etiology of cardiovascular dysfunctions evoked by stress are still poorly understood. Thus, ...
Efeito da variação diária na temperatura corporal no incremento metabólico pós-prandial (SDA) da espécie Lithobates Catesbeianus
(Universidade Federal de São Carlos, 2019-08-30)
Introduction: The postprandial metabolic increment is characterized by a fast elevation in postprandial metabolic rate. The increase in O2 consumption continues until reaching a peak of consumption, that may occur days ...
Efeitos do treinamento resistido sobre a expressão gênica de moléculas envolvidas na oxidação de gordura e na lipogênese no fígado de ratas ovariectomizadas
(Universidade Federal de São Carlos, 2011-06-17)
Decreased levels of estrogen are associated with hepatic steatosis (HS), through changes in gene expression of molecules related to fat oxidation and lipogenesis. Both resistance training (RT) and endurance training (ET) ...