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Regulação da temperatura corporal : sensores e efetores térmicos
(Universidade Federal de São Carlos, 2016-02-12)
In this study, we aimed at investigating the involvement of the warmth-sensitive channel – TRPV4 (in vitro sensitive to temperatures in the range of approx. 24–34°C) – on the thermoregulatory mechanisms in rats. We treated ...
Utilização do complexo de rutênio cis- [Ru(bpy)2(NO2)(NO)](PF6)2) para reverter e/ou prevenir a disfunção endotelial na hipertensão arterial
(Universidade Federal de São Carlos, 2016-04-14)
The endothelium is a monolayer of cells that extends on the vascular inner surface,
responsible for the modulation of vascular tone. By means of the release of nitric
oxide (NO), the endothelium has an important protective ...
Participação dos receptores opióides mu e kappa da substância cinzenta periaquedutal na febre induzida por estresse de contenção
(Universidade Federal de São Carlos, 2016-07-15)
The endogenous opioids are involved in analgesia, thermoregulation and physiological responses to various stressful stimuli such as infection, psychological stress and hypoxia. The mu and kappa receptors in the hypothalamus ...
Biomarcadores sanguíneos para a doença de Alzheimer : avaliação da expressão gênica da ADAM10 e de micro- RNAs
(Universidade Federal de São Carlos, 2016-03-11)
ADAM10 is an-secretase that cleaves APP in the non-amyloidogenic pathway, thereby inhibiting -amyloid peptide (A ) production in Alzheimer´s disease (AD). Studies have shown decreased ADAM10 platelet levels in AD patients ...
N-acetilcisteína bloqueia o desenvolvimento da sensibilização comportamental ao etanol e as alterações na proteína (Delta)FosB
(Universidade Federal de São Carlos, 2016-02-26)
Ethanol addiction is a serious public health problem that still needs more effective pharmacological treatment. A key factor in the development and maintenance of this disease is the development of neural plasticity that ...
Inflamação no tecido adiposo visceral em ratas ovariectomizadas : efeitos do treinamento resistido e da reposição de estrogêni
(Universidade Federal de São Carlos, 2016-03-30)
The ovariectomy associated with decreased estrogen is associated with increased prevalence
of obesity, a condition that increases the risk of metabolic syndrome. Evidence shows that
inflammation-induced obesity in visceral ...
Efeitos antitumorais e antimetastáticos de novos complexos de rutênio em células de câncer de mama
(Universidade Federal de São Carlos, 2016-04-29)
Brazil and the world are passing through demographic changes as consequences of population
urbanization, industrialization and advances in science and technology. This process,
associated with the transformation of ...
Alterações cardiovasculares induzidas pela obesidade : envolvimento do sistema reninaangiotensina no núcleo do trato solitário
(Universidade Federal de São Carlos, 2016-02-01)
In the last decades, obesity has become a worldwide epidemy. Excess of adipose tissue favors the development of associated diseases such as hypertension, obstructive sleep apnea and type II diabetes. Data from the literature ...
Efeitos do treinamento físico na hipertensão e na atrofia muscular em ratos tratados com dexametasona
(Universidade Federal de São Carlos, 2016-03-29)
Dexamethasone (DEX) is widely used due to its potent anti-inflammatory effect,
although its chronic use may cause unwanted effects, including arterial hypertension (H)
and muscle atrophy. The mechanisms responsible for ...
Modulação dos receptores 5-HT1A e 5-HT2C DO complexo amigdalóide sobre os efeitos da fluoxetina na antinocicepção induzida pelo confinamento de camundongos aos braços do labirinto em cruz elevado
(Universidade Federal de São Carlos, 2016-03-23)
Previous studies have implicated the 5HT1A and 5HT2C serotonin receptors subtypes located within the amygdala in the modulation of defensive behaviors in rodents exposed to the elevated plus-maze (EPM). Further studies ...