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Biomarcadores sanguíneos para a doença de Alzheimer : avaliação da expressão gênica da ADAM10 e de micro- RNAs
(Universidade Federal de São Carlos, 2016-03-11)
ADAM10 is an-secretase that cleaves APP in the non-amyloidogenic pathway, thereby inhibiting -amyloid peptide (A ) production in Alzheimer´s disease (AD). Studies have shown decreased ADAM10 platelet levels in AD patients ...
Treinamento resistido e reposição hormonal aumentam a atividade das metaloproteinases-2 e a qualidade de osso de ratas ovariectomizadas
(Universidade Federal de São Carlos, 2016-09-16)
Purpose: The aim of the present study was to investigate the influence of resistance training (RT) and hormone replacement (HR) on MMP-2 activity, biomechanical and physical properties bone of ovariectomized (OVX) rats. ...
Remodelamento da matriz extracelular e respostas cardíacas funcionais em ratos idosos submetidos a treinamento resistido
(Universidade Federal de São Carlos, 2016-03-04)
INTRODUCTION: It is well documented that aging causes morphological and functional alterations in the heart. Cardiac ECM remodeling is one event of structural changes in left ventricle (LV), which is modulated by MMPs/TIMPs ...
Investigação do tratamento com N-acetilcisteína nos comportamentos relacionados à ansiedade durante a síndrome de abstinência do etanol e na resposta cardiovascular induzida pelo estresse em ratos
(Universidade Federal de São Carlos, 2019-02-08)
N-acetylcysteine (NAC) for decades, has been shown to have beneficial effects for the treatment of some diseases. Recently, based on central glutamatergic neurotransmission, psychiatric disorders and the stress response ...
ADAM10 como biomarcadora de Transtorno Neurocognitivo Leve
(Universidade Federal de São Carlos, 2020-09-28)
Mild cognitive impairment (MCI), in the absence of dementia, and associated with physical frailty gave rise to the new concept called cognitive frailty. This new concept has also been considered as a subtype of frailty. ...