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Avaliação do potencial antimicrobiano de nanoemulsões à base de compostos de óleos essenciais no controle de espécies de Xanthomonas causadoras do cancro cítrico
(Universidade Federal de São Carlos, 2020-11-27)
Citrus canker is one of the most relevant diseases that affect citrus crops, being responsible for serious economic losses to citrus fruit producers and traders. This disease is caused by Gram-negative bacteria of the genus ...
A autofagia é necessária para a segregação de DNA mitocondrial no Fígado
(Universidade Federal de São Carlos, 2021-06-24)
Mutations in the mitochondrial genome (mtDNA) are ubiquitous in humans and can lead to a broad spectrum of disorders. However, due to the presence of multiple mtDNA molecules in the cell, coexistence of mutant and wild-type ...
Nanoformulação do [10]-Gingerol em células de câncer de mama triplo negativo
(Universidade Federal de São Carlos, 2020-10-08)
Breast cancer is the neoplasm that most affects women worldwide and can be classified into different types. Among them, triple negative breast cancer (TN) is characterized by not having hormone receptors, nor receptors for ...
Aplicabilidade clínica da técnica CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) no tratamento da anemia falciforme: uma revisão integrativa
(Universidade Federal de São Carlos, 2020-12-18)
Introduction and objective: Sickle cell disease is the most common hemoglobinopathy in humans and has a high morbidity and mortality rates. It is caused by a point mutation, an A-T substitution (GAG→GTG) in the first exon ...
Análise in silico de um novo composto possível inibidor de ciclooxigenase 2 utilizando docking molecular
(Universidade Federal de São Carlos, 2021-01-04)
This work describes the study of the formation of complexes between the enzyme cyclooxygenase (COX-2) and some of its inhibitors. For this purpose, the known inhibitors celecoxib (CEL), rofecoxib (RCX) and Korean 21 and ...
Clonagem e expressão de uma xilanase presente no (Meta)transcriptoma do Cupim da espécie Heterotermes tenuis e sua importante aplicação na produção de biocombustíveis
(Universidade Federal de São Carlos, 2021-01-08)
Xylanases are an important group of enzymes responsible for the hydrolysis of the xylan glycosidic chain forming xylose and xylobiosis. Mainly noteworthy is endo-1,4-β-xylanase, a hemicellulase capable of cleaving the β-1,4 ...
Análise filogeográfica do segmento genômico da proteína neuraminidase do H1N1 no Brasil
(Universidade Federal de São Carlos, 2022-04-18)
Seasonal flu, caused by Influenza viruses, is one of the most prevalent viral infections in the world, causing 290-650 thousand deaths annually. Such viruses, whose genome is composed of negatively oriented single-stranded ...
Investigação de moléculas híbridas para o tratamento anticâncer
(Universidade Federal de São Carlos, 2022-07-06)
Cancer is the attribution given to the uncontrolled growth and proliferation of abnormal cells capable of invading and destroying the adjacent tissue. According to the World Health Organization (WHO), the global growth in ...
Os cromossomos sexuais como fonte geradora de diferenciação genética. O gênero Pyrrhulina (Characiformes, Lebiasinidae) como modelo
(Universidade Federal de São Carlos, 2021-11-11)
Allopatric processes are generally considered among the main causes of the striking
Neotropical biodiversity. However, the role of chromosomal rearrangements and neo-sex
chromosomes in genetic diversity and speciation ...
Aprendizado de Máquina para classificação das linhagens de Copia e Gypsy de angiospermas
(Universidade Federal de São Carlos, 2021-12-17)
This study used machine learning algorithms (neural network, decision tree and close neighbors algorithm) to create classification models of 11 lineages of the Copia and Gypsy superfamilies, using angiosperm DNA sequences ...