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Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study

dc.contributor.authorHeubel, Alessandro Domingues
dc.contributor.authorViana, Ariane Aparecida
dc.contributor.authorLinares, Stephanie Nogueira
dc.contributor.authorAmaral, Vanessa Teixeira do
dc.contributor.authorSchafauser, Nathany Souza
dc.contributor.authorOliveira, Gustavo Yudi Orikassa de
dc.contributor.authorRamírez, Paula Camila
dc.contributor.authorMartinelli, Bruno
dc.contributor.authorAlexandre, Tiago da Silva
dc.contributor.authorSilva, Audrey Borghi
dc.contributor.authorCiolac, Emmanuel Gomes
dc.contributor.authorMendes, Renata Gonçalves
dc.date.accessioned2022-02-09T10:19:21Z
dc.date.available2022-02-09T10:19:21Z
dc.date.issued2021-11-23
dc.identifierhttps://doi.org/10.1002/oby.23311por
dc.identifier.citationHEUBEL, Alessandro Domingues; VIANA, Ariane Aparecida; LINARES, Stephanie Nogueira; AMARAL, Vanessa Teixeira do; SCHAFAUSER, Nathany Souza; OLIVEIRA, Gustavo Yudi Orikassa de; RAMÍREZ, Paula Camila; MARTINELLI, Bruno; ALEXANDRE, Tiago da Silva; SILVA, Audrey Borghi; CIOLAC, Emmanuel Gomes; MENDES, Renata Gonçalves. Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study. Repositório Institucional da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15570.*
dc.identifier.urihttps://repositorio.ufscar.br/handle/ufscar/15570
dc.descriptionObjective: The aim of this study was to identify determinants of endothelial dysfunction in patients hospitalized with acute COVID-19. Methods: A total of 109 hospitalized COVID-19 patients in noncritical status were cross-sectionally studied. Clinical data (age, sex, comorbidities, and medications) and BMI were assessed. Laboratory tests included serum hemoglobin, leukocytes, lymphocytes, platelets, C-reactive protein, ferritin, D-dimer, and creatinine. Physical status was evaluated using a handgrip dynamometer. Endothelial function was assessed noninvasively using the flow-mediated dilation (FMD) method. Results: The sample average age was 51 years, 51% of patients were male, and the most frequent comorbidity was obesity (62%). Univariate analysis showed association of lower FMD with higher BMI, hypertension, use of oral antihypertensive, higher blood levels of creatinine, and larger baseline artery diameter. After adjusting for confounders, the multivariate analysis showed BMI (95% CI: −0.26 to −0.11; p < 0.001) as the major factor associated with FMD. Other factors associated with FMD were baseline artery diameter (95% CI: −1.77 to −0.29; p = 0.007) and blood levels of creatinine (95% CI: −1.99 to −0.16; p = 0.022). Conclusions: Increased BMI was the major factor associated with endothelial dysfunction in noncritically hospitalized COVID-19 patients. This may explain one of the pathways in which obesity may increase the risk for severe COVID-19.eng
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)por
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)por
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.language.isoengeng
dc.publisherUniversidade Federal de São Carlospor
dc.relation.urihttps://pubmed.ncbi.nlm.nih.gov/34554646/por
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectCovid-19eng
dc.subjectEndothelial functioneng
dc.titleDeterminants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional studyeng
dc.typeDataseteng
dc.publisher.initialsUFSCarpor
dc.publisher.programPrograma de Pós-Graduação em Fisioterapia - PPGFtpor
dc.subject.cnpqCIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONALpor
dc.description.sponsorshipIdCódigo de Financiamento 001 - CAPESpor
dc.description.sponsorshipIdProcesso nº 2015/09259‐2, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.description.sponsorshipIdProcesso nº 2015/26501‐1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.description.sponsorshipIdProcesso nº 303399/2018‐0 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)por
dc.publisher.addressCâmpus São Carlospor
dc.contributor.authorlatteshttp://lattes.cnpq.br/0268406461810882por
dc.contributor.authorlatteshttp://lattes.cnpq.br/1481298729632703por
dc.contributor.authorlatteshttp://lattes.cnpq.br/4807021719144918por
dc.contributor.authorlatteshttp://lattes.cnpq.br/1062630392712013por
dc.contributor.authorlatteshttp://lattes.cnpq.br/5075933151971198por
dc.contributor.authorlatteshttp://lattes.cnpq.br/7445487787814347por
dc.contributor.authorlatteshttp://lattes.cnpq.br/9108932694410237por
dc.contributor.authorlatteshttp://lattes.cnpq.br/7026690603304796por
dc.contributor.authorlatteshttp://lattes.cnpq.br/5393622641681701por
dc.contributor.authorlatteshttp://lattes.cnpq.br/4855616925791895por
dc.contributor.authorlatteshttp://lattes.cnpq.br/0323573809193832por
dc.contributor.authorlatteshttp://lattes.cnpq.br/9634590922242052por
dc.publisher.departmentDepartamento de Fisioterapia - DFisiopor


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