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Formação de complexos entre compostos híbridos pirrolbenzodiazepinas-cumarinas com DNA por estudos de docking molecular
(Universidade Federal de São Carlos, 2011-03-24)
Compounds of the pirrolbenzodiazepine (PBD) family are known for their promising antitumor activity. Among these, the hybrids, those that have a portion PDB a chain spacer and another functional group, such as the coumarins ...
Modelagem molecular de derivados pirimidínicos e estudos de docking nas enzimas ciclooxigenase 1 e ciclooxigenase 2
(Universidade Federal de São Carlos, 2010-11-23)
In this research molecular docking was used to study enzime-ligand complexes of Cyclooxygenase 1 (COX-1) and Cyclooxygenase 2 (COX-2) with pyrimidine derivatives, aiming at understanding the possible mechanisms of action ...
Docking de herbicidas na glutationa transferase tau4-4 de soja (Glycine max)
(Universidade Federal de São Carlos, 2011-03-30)
This study, based on molecular docking, describes the search for the most favorable conformations when complexes between herbicides, used in soybean cultivation, and an enzyme involved in the detoxification process are ...
Docking molecular aplicado ao estudo da formação de complexos entre análogos de resveratrol e derivados de 1,2,3-triazol e a enzima COX-2
(Universidade Federal de São Carlos, 2011-12-14)
Prostaglandin H synthases (PGHS), or cyclooxygenases (COX), are known to exist in at least two isoforms, COX-1 and COX-2, encoded by different genes. COX s play a central role in the inflammatory cascade by converting ...
Docking de compostos da família das ariloxazinas em enzimas relacionadas com a malária
(Universidade Federal de São Carlos, 2010-08-06)
Malaria disease, caused mainly by Plasmodium falciparum parasite, afflicts about 500 million people and causes nearly one million deaths every year. For the development of new drugs against this disease, one possible ...
Estudos estruturais de duas 3 (Fenoximetil)-4-fenilbut-3-en-onas e docking no fator letal (LF) do bacillus anthracis (Antraz)
(Universidade Federal de São Carlos, 2014-08-28)
In this work the crystal structures of two 3 (phenoxymethyl)-4-phenylbut-3-en-ones were determined and the resulting 3D strutures were used as input for docking studies in the lethal factor (LF) of bacillus anthracis. The ...
Nanopartículas de grafite para carreamento de antiinflamatórios não esteroidais por estudos de docking molecular
(Universidade Federal de São Carlos, 2013-08-13)
The non steroidal anti-inflammatory drugs have been known for over 100 years and has been widely used by mankind. However cause adverse effects, since gastrointestinal complications to cardiac diseases many of these symptoms ...