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Efeito das enzimas recombinantes de Schistosoma mansoni Hipoxantina-Guanina Fosforibosiltransferase (HGPRT) e Purina Nucleosídeo Fosforilase (PNP) no tratamento da esquistossomose experimental
(Universidade Federal de São Carlos, 2018-02-26)
Schistosomiasis is a disease that affects a large number of people in 78 countries. The
number of cases has increased in recent years and there is no vaccine and new drugs, a
worrying aspect, since there is loss of ...
Deleção oócito-específica da Rad51 em murinos e seu impacto sobre a função mitocondrial e a fertilidade
(Universidade Federal de São Carlos, 2020-02-14)
One of the first signs of aging in humans is the decrease in female fertility, which is
accompanied by a reduction in the expression of proteins that integrate the Double Strand Break
(DSB) repair machinery, such as ...
Utilizando ferramentas da genética forense para investigar a origem dos indivíduos do canário-da-terra (Sicalis flaveola) mantidos em cativeiro
(Universidade Federal de São Carlos, 2020-03-31)
Wildlife protection is a global priority issue. International treaties, laws, national entities and organizations fight for the conservation of biodiversity and protection of wildlife, generating environmental awareness ...
Variantes reguladoras associadas à expressão alelo-específica (aseQTL) em músculo de Nelore (Bos indicus)
(Universidade Federal de São Carlos, 2020-02-27)
Brazil is a significant exporter of beef, so the improvement of Nelore, a breed mostly present
in the Brazilian herd, directly impact this sector. Genomic tools can identify SNPs associated
with interesting livestock ...
Prospecção de regiões pleiotrópicas para características complexas relevantes ao melhoramento bovino a partir de GWAS bi-característica
(Universidade Federal de São Carlos, 2019-05-31)
The demand for sustainable beef production systems drives the development of new tools that aim to reduce the production costs and to avoid losses in meat quality. The objective of this study was to identify possible ...
Impacto da deleção oócito-específica de Rad51 sobre o DNA mitocondrial e a divisão meiótica em murinos
(Universidade Federal de São Carlos, 2020-02-28)
RAD51 is a protein of eukaryotic organisms, with a central role in the DNA repair pathway by homologous recombination. Its function in the nucleus of somatic cells is well established, being necessary for the maintenance ...
Determinantes estruturais da bioluminescência vermelha e eficiência catalítica na luciferase de phrixothrix hirtus e seleção de combinação emissora de luz vermelha distante com 6´-amino-análogos de luciferina
(Universidade Federal de São Carlos, 2019-12-06)
Luciferases are the enzymes responsible for bioluminescence. These enzymes catalyze the oxidation of luciferins, in which the energy is released in the form of light with high efficiency. The luciferases fireflies from ...
Distribuição da variação genética nos canídeos Cerdocyon thous e Chrysocyon brachyurus de paisagens antropizadas da região centro-oeste e sudeste do Brasil
(Universidade Federal de São Carlos, 2017-08-24)
The Crab-eating fox (Cerdocyon thous) and the Maned Wolf (Chrysocyon brachyurus) are a fundamental part from the habitats where they occur, due to the ecosystemic functions they play, as seed dispersers and controlling the ...
Desenvolvimento de biossensores raciométricos bioluminescentes de ph e metais divalentes baseados na engenharia da região sensível ao pH nas luciferases de vagalumes
(Universidade Federal de São Carlos, 2017-12-01)
Bioluminescence, the emission of visible light by living organisms is widely used in biosensors. Firefly luciferases and genes are among the most used reporter gene in bioluminescent biosensors. Firefly luciferases are ...
Montagem e análise taxonômica-funcional de transcriptomas de espécies de cupins brasileiros
(Universidade Federal de São Carlos, 2020-02-28)
Termites (Isoptera) are eusocial insects that stand out for their hierarchical and structural organization, demonstrating complex social behaviors, numerous symbiotic interactions, and a great potential for bioprospecting ...