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Investigação dos mecanismos envolvidos na herança mitocondrial: o papel da dinâmica mitocondrial
(Universidade Federal de São Carlos, 2020-10-08)
Diseases caused by mutations in mitochondrial DNA (mtDNA) are the most common genetic diseases in humans. Despite this, there is no effective treatment for these diseases and the mechanisms of inheritance are not fully ...
Efeito citotóxico e pró-apoptótico do composto [6]-Shogaol contra células de câncer de bexiga (MB49), in vitro
(Universidade Federal de São Carlos, 2021-05-24)
Bladder cancer is considered one of the most aggressive malignancies due to its profile of recurrence and progression, and even with the improvement in methods of diagnosis and treatment, the mortality rate has not shown ...
Eficácia da instilação de células da linhagem MB49 e gel polimérico termorreversível na imunização contra o carcinoma urotelial de bexiga
(Universidade Federal de São Carlos, 2020-09-24)
Among the various types of malignant neoplasms, those originating in the bladder can be considered highly impactful due to their prevalence and high recurrence rates, demonstrating the importance of studies involving new ...
Viabilidade de grãos de pólen de espécies de Paspalum após a criopreservação visando seu uso em programas de melhoramento genético
(Universidade Federal de São Carlos, 2020-02-28)
Paspalum is a genus of the Poaceae family, native to America, of which many species have forage potential. The high natural genetic diversity observed in the genus can be used to obtain and launch new cultivars. For ...
Análise dos transcriptomas de Paspalum notatum Flúggé e Paspalum vaginatum Swartz em condição de déficit hídrico
(Universidade Federal de São Carlos, 2020-02-19)
Drought is one of the abiotic stresses that most affect plant growth and productivity. Grasses of the genus Paspalum are used successfully in pastures and lawns, and some ecotypes of Paspalum notatum (bahiagrass) have good ...
Caracterização da antigenicidade e do efeito protetor em modelo murino de proteínas recombinantes de Erysipelothrix rhusiopathiae candidatas a antígenos vacinais
(Universidade Federal de São Carlos, 2020-02-18)
Erysipelothrix rhusiopathiae is a gram-positive, bacilliform, and encapsulated bacterium that
causes swine erysipelas, a disease characterized by skin lesions and other symptoms such
as septicemia, arthritis, and ...
Clonagem e caracterização das isoformas de luciferases de lanternas e corpo gorduroso do vagalume Aspisoma lineatum (Lampyridae: Cratomorphini): origem estrutural e evolutiva das luciferases pH-sensitivas mais eficientes à partir de ancestrais pH-insensitivas
(Universidade Federal de São Carlos, 2020-10-31)
Firefly luciferases emit yellow-green light with high efficiency at physiological pH. However, under acidic conditions, in the presence of heavy metals or high temperatures, they emit red light. To understand the structural ...
Cistatinas de cana-de-açúcar: produção recombinante em vacúolos de cana-de-açúcar transgênica (e outros sistemas de expressão em plantas) e estudos de interação com uma pseudo protease do coleóptero Sphenophorus levis
(Universidade Federal de São Carlos, 2021-03-29)
Sphenophorus levis (Curculionidae: Coleoptera) is one of the major pests of sugarcane crop in Brazil and presents cysteine proteases as main digestive enzymes. In this project, we report the characterization of Sl-CathL-CS, ...
Estudo dos efeitos antiangiogênicos da desintegrina-símile Alternagina-C (ALT-C) em células endoteliais (HUVEC), tendo como alvo a integrina α2β1
(Universidade Federal de São Carlos, 2020-03-04)
Angiogenesis is a crucial process in tumor progression, and it is mainly regulated by the vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. Studies have shown that VEGF/VEGFR2 axis signaling is directly ...
A integrina a2b1 na progressão tumoral mamária: papel no microambiente tumoral e na metástase
(Universidade Federal de São Carlos, 2019-08-23)
The harmonic functioning of cells involves an orchestrated synchronization of signaling that maintains the balance between proliferation and cell death in healthy tissues. Eventually, gene mutations can occur and the ...