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Mapeamento proteico da matriz do esmalte de incisivos de camundongos susceptíveis e resistentes à fluorose dentária
(Universidade Federal de São Carlos, 2015-08-12)
Enamel formation is a two-step complex process by which proteins are first secreted to forming an extracellular matrix, followed by massive protein degradation simultaneously with the completion of mineralization. Excessive ...
Potencial antitumoral das proteínas TRAIL e IL-2 expressas e veiculadas por Salmonella Typhimurium atenuada em modelo de câncer colorretal
(Universidade Federal de São Carlos, 2019-10-14)
Colorectal cancer is the third most diagnosed malignant disease and the fourth leading cause of cancer-related deaths in the world. Cancer treatments are not fully effective and low selectivity to tumor tissue has marked ...
Caracterização funcional e bioquímica do fator de transcrição rlmA e da interação de PkcA e Hsp90 no fungo Aspergillus fumigatus
(Universidade Federal de São Carlos, 2017-12-18)
Aspergillus fumigatus is an opportunistic human pathogen that causes systemic infections, including invasive pulmonary aspergillosis in immunocompromised individuals. Survival of this fungus is highly dependent on the cell ...
Degradação de matéria orgânica terrestre por microrganismos do rio Amazonas – Metagenômica e genômica populacional
(Universidade Federal de São Carlos, 2018-12-14)
Microbes from Amazon river basin represent an unexplored biodiversity, with a huge metabolic potential. This ecosystem receives large amounts of terrestrial organic matter (OM), which promotes heterotrophic microbial growth. ...
Investigação dos mecanismos envolvidos na herança mitocondrial: o papel da dinâmica mitocondrial
(Universidade Federal de São Carlos, 2020-10-08)
Diseases caused by mutations in mitochondrial DNA (mtDNA) are the most common genetic diseases in humans. Despite this, there is no effective treatment for these diseases and the mechanisms of inheritance are not fully ...