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Efeito do tratamento com hidroxiureia sobre a expressão gênica de ATF4, MSN, PBXIPI e SNCA em pacientes com anemia falciforme e em células K562
(Universidade Federal de São Carlos, 2020-03-06)
Our study aimed to analyze the expression and protein content of four genes (ATF4, MSN, PBXIP1 and SNCA) by qPCR and Western Blotting in individuals with sickle cell anemia treated and not treated with hydroxyurea (HU) in ...
Papel da proteína Fbxo7 no perfil de citocinas produzidas em linhagem celular monocítica humana (THP-1) estimulada por lipopolissacarídeo
(Universidade Federal de São Carlos, 2021-05-24)
The canonical function of SCF E3 ubiquitin ligase complexes is the ubiquitination of their substrates, directing them to proteasomal degradation or modulation of function. From these complexes, F-box protein class is the ...
Efeito citotóxico e pró-apoptótico do composto [6]-Shogaol contra células de câncer de bexiga (MB49), in vitro
(Universidade Federal de São Carlos, 2021-05-24)
Bladder cancer is considered one of the most aggressive malignancies due to its profile of recurrence and progression, and even with the improvement in methods of diagnosis and treatment, the mortality rate has not shown ...
Triagem de isolados clínicos de Leishmania sp. para sequenciamento genômico
(Universidade Federal de São Carlos, 2020-06-22)
Leishmaniasis is a group of infectious tropical disease caused by protozoan from genus Leishmania and transmitted to humans through bites of infected sand flies. Visceral Leishmaniasis (VL) is the most severe clinical form ...
Análise funcional do gene que codifica xiluloquinase em Xanthomonas citri
(Universidade Federal de São Carlos, 2022-06-23)
Citrus canker causes a decrease in the productivity and quality of citrus fruits due to the lack of efficient control and eradication measures and is caused by the bacterium Xanthomonas citri subsp citri (XAC). In proteomics ...
Seleção e caracterização molecular e fermentativa de leveduras personalizadas para a produção de vinhos brasileiros
(Universidade Federal de São Carlos, 2022-03-04)
Brazilian wine production has been standing out with high quality awarded wines around the world. However, major changes are still needed so that our country can compete with other wineries in the world. Among them, we can ...
Desenvolvimento de um banco de dados de SNPs humanos relacionados a doenças virais
(Universidade Federal de São Carlos, 2022-07-27)
Viruses are agents that can cause several human diseases, but the individual response can be distinct. Genetic factors can affect the susceptibility and host therapy response to certain viral diseases. The research for ...
Expressão recombinante de endo-beta-1,4 xilanase identificada no meta-transcriptoma de cupins da espécie Heterotermes tenuis para produção de bioetanol
(Universidade Federal de São Carlos, 2022-02-22)
The search for alternative energy sources to the consumption of petroleum and the attention to the environment has awakened the use of new bases in biofuels. In line with this is second-generation ethanol (E2G), which can ...
Cistatinas de maqui: produção recombinante e inibição de cisteíno peptidases
(Universidade Federal de São Carlos, 2022-02-15)
Cystatins are tight binding competitive inhibitors of cysteine peptidases. In plants, they act regulating different physiological mechanisms, as well as defending from biotic and abiotic stresses, making them of potential ...
Enriquecimento ambiental e a modulação da emocionalidade, cuidado materno e metilação de genes em camundongos fêmeas LG/J
(Universidade Federal de São Carlos, 2022-08-30)
Environmental Enrichment (EE) can be considered as a set of environmental changes that can adjust the model of a species and favor well-being in captive animals. The present study intends to investigate the influence of ...