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Identificação de ligantes e substratos do complexo E3 ubiquitina-ligase SCF(FBXL17)
(Universidade Federal de São Carlos, 2022-02-10)
Fbxl17 is one of the 69 F-box (Fbx) proteins in humans capable of interaction with SKP1,
Cullin 1 and Rbx1 to form the E3 ubiquitin ligase complex SCF(Fbxl17). The SCF(Fbxl17)
complex is the major class of human E3 ...
Sítios cromossômicos instáveis e diversificação cariotípica em Loricariidae: análise citogenética e molecular
(Universidade Federal de São Carlos, 2022-07-15)
Loricariidae includes species vulgarly known as armored catfishes. Cytogenetic data revealed wide chromosomal diversity in this family, resulted from both diploid number (2n) variation, because of centric fusion events, ...
Caracterização de pontos de quebras de DNA e rearranjos cromossômicos no gênero Harttia (Siluriformes: Loricariidae)
(Universidade Federal de São Carlos, 2022-04-04)
Harttia genus comprises a fish group widely distributed in hydrographic basins of South
America. In the cytogenetic point of view, present large karyotypic variation, including
an extensive variation in position of ...
Isolamento e caracterização de vB_XciM_LucasX, um novo bacteriófago lítico de Xanthomonas citri e Xanthomonas fuscans
(Universidade Federal de São Carlos, 2022-09-16)
Citrus canker, which is caused by the bacteria Xanthomonas citri and Xanthomonas fuscans, is one of the main diseases that affect the citrus industry in Brazil. Disease control methods are available, but new methods are ...
Clonagem e caracterização das isoformas de luciferases de lanternas e corpo gorduroso do vagalume Aspisoma lineatum (Lampyridae: Cratomorphini): origem estrutural e evolutiva das luciferases pH-sensitivas mais eficientes à partir de ancestrais pH-insensitivas
(Universidade Federal de São Carlos, 2020-10-31)
Firefly luciferases emit yellow-green light with high efficiency at physiological pH. However, under acidic conditions, in the presence of heavy metals or high temperatures, they emit red light. To understand the structural ...
Cistatinas de cana-de-açúcar: produção recombinante em vacúolos de cana-de-açúcar transgênica (e outros sistemas de expressão em plantas) e estudos de interação com uma pseudo protease do coleóptero Sphenophorus levis
(Universidade Federal de São Carlos, 2021-03-29)
Sphenophorus levis (Curculionidae: Coleoptera) is one of the major pests of sugarcane crop in Brazil and presents cysteine proteases as main digestive enzymes. In this project, we report the characterization of Sl-CathL-CS, ...
Estudo dos efeitos antiangiogênicos da desintegrina-símile Alternagina-C (ALT-C) em células endoteliais (HUVEC), tendo como alvo a integrina α2β1
(Universidade Federal de São Carlos, 2020-03-04)
Angiogenesis is a crucial process in tumor progression, and it is mainly regulated by the vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. Studies have shown that VEGF/VEGFR2 axis signaling is directly ...
Nova proposta didática para o ensino de biologia molecular na educação básica
(Universidade Federal de São Carlos, 2022-04-07)
The teaching of science and biology in basic education aims to provide minimum content so that individuals can deal with new information and are able to understand, question and position themselves in the face of ethical ...
Imunoterapia com IL-2 e TRAIL expressas por Salmonella recombinante contra o câncer de bexiga
(Universidade Federal de São Carlos, 2022-12-19)
IL-2 and TRAIL are therapeutic agents known for their antitumor role, but they can be rapidly
cleared by the body or be toxic, compromising their function. To reverse this impasse, the synthesis
of these agents by living ...
Análise toxicológica da nanopartícula de óxido de ferro misto (NP Fe3O4) com ligantes de sulfonato de sódio (SO3)-Na+): in vitro e in vivo
(Universidade Federal de São Carlos, 2022-10-25)
Known for their biocompatible potential and magnetic property, iron oxide nanoparticles are the target of several studies for different applications. However, the synthesis of new nanoparticles with different physicochemical ...