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Efeito das enzimas recombinantes de Schistosoma mansoni Hipoxantina-Guanina Fosforibosiltransferase (HGPRT) e Purina Nucleosídeo Fosforilase (PNP) no tratamento da esquistossomose experimental
(Universidade Federal de São Carlos, 2018-02-26)
Schistosomiasis is a disease that affects a large number of people in 78 countries. The
number of cases has increased in recent years and there is no vaccine and new drugs, a
worrying aspect, since there is loss of ...
Aspectos filogeográficos de Leporinus cf. friderici e da distribuição da diversidade genética em Leporinus cf. friderici Paraná e Megaleporinus obtusidens na bacia do Alto Paraná
(Universidade Federal de São Carlos, 2018-10-05)
The megadiversity of the Neotropical ichthyofauna has been associated to recent diversification processes, reflecting in subtle or lacking morphological differentiation between species, challenging the classical taxonomic ...
Determinantes estruturais da bioluminescência vermelha e eficiência catalítica na luciferase de phrixothrix hirtus e seleção de combinação emissora de luz vermelha distante com 6´-amino-análogos de luciferina
(Universidade Federal de São Carlos, 2019-12-06)
Luciferases are the enzymes responsible for bioluminescence. These enzymes catalyze the oxidation of luciferins, in which the energy is released in the form of light with high efficiency. The luciferases fireflies from ...
Desenvolvimento de biossensores raciométricos bioluminescentes de ph e metais divalentes baseados na engenharia da região sensível ao pH nas luciferases de vagalumes
(Universidade Federal de São Carlos, 2017-12-01)
Bioluminescence, the emission of visible light by living organisms is widely used in biosensors. Firefly luciferases and genes are among the most used reporter gene in bioluminescent biosensors. Firefly luciferases are ...
Evolução cromossômica na família Lebiasinidae (Teleostei, Characiformes), com enfoque em espécies do gênero Lebiasina
(Universidade Federal de São Carlos, 2020-02-06)
The Lebiasinidae family is composed by seven genus of small freshwater fishes that can be found in small rivers of Central and South America. Members of this family presents a great diversity in form and body color, but ...
Efeitos citotóxicos e genotóxicos de uma nova nanopartícula de titânio de interesse industrial - in vitro
(Universidade Federal de São Carlos, 2020-02-18)
Titanium dioxide nanoparticles (TiO2 NP) are included as one of the most used nanomaterials by industries in general; it is applied in coatings, pigments, and paints for its ability to offer opacity and brightness, in ...
Eficácia da instilação de células da linhagem MB49 e gel polimérico termorreversível na imunização contra o carcinoma urotelial de bexiga
(Universidade Federal de São Carlos, 2020-09-24)
Among the various types of malignant neoplasms, those originating in the bladder can be considered highly impactful due to their prevalence and high recurrence rates, demonstrating the importance of studies involving new ...
Inibidores de poligalacturonase (PGIPs) oriundos do feijão: produção recombinante e estudos funcionais
(Universidade Federal de São Carlos, 2019-03-01)
Pectic substances are components of the middle lamella of the plant cell wall and are composed of partially methyl-esterified galacturonic acid residues linked by α-1,4 glycosidic bonds. These substances are naturally ...
Caracterização da antigenicidade e do efeito protetor em modelo murino de proteínas recombinantes de Erysipelothrix rhusiopathiae candidatas a antígenos vacinais
(Universidade Federal de São Carlos, 2020-02-18)
Erysipelothrix rhusiopathiae is a gram-positive, bacilliform, and encapsulated bacterium that
causes swine erysipelas, a disease characterized by skin lesions and other symptoms such
as septicemia, arthritis, and ...
Investigação dos mecanismos envolvidos na herança mitocondrial: o papel da dinâmica mitocondrial
(Universidade Federal de São Carlos, 2020-10-08)
Diseases caused by mutations in mitochondrial DNA (mtDNA) are the most common genetic diseases in humans. Despite this, there is no effective treatment for these diseases and the mechanisms of inheritance are not fully ...