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Síntese de derivados de chalconas e de 2-quinolinonas visando a busca por inibidores das enzimas cruzaína e da família BET bromodomain
(Universidade Federal de São Carlos, 2014-09-12)
The first part of this work involved the synthesis of chalcone derivatives towards the development of inhibitors of the enzyme cruzain from Trypanosoma cruzi. Different green chemistry approaches were employed to functionalize ...
Síntese de uma coleção de cumarinas, possíveis inibidores da enzima acetilcolinesterase
(Universidade Federal de São Carlos, 2010-08-13)
Alzheimer's disease is associated with decreased rates of acetylcholine (ACh) in synaptic process, decreasing the cortical cholinergic transmission, and other neurotransmitters such as norepinephrine, dopamine, serotonin, ...