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Citotoxidade e mecanismo de ação de complexos Ru(II)/2-mercapto-4(3H)quinazolinona em células de câncer de pele
(Universidade Federal de São Carlos, 2023-02-28)
Ruthenium biphosphynic complexes combined with mercapto ligands have shown low IC50 values and good selectivity indexes (SI) in different tumor lines studied, which has motivated the development of ruthenium compounds with ...
Influência do tipo de lipídeo e peptídeo beta amiloide sobre a perturbação da membrana e consequências na toxicidade de células neuronais observadas pelas respostas luminescentes do complexo RuApy
(Universidade Federal de São Carlos, 2023-08-28)
One of the hypotheses for the cause of Alzheimer's disease is the accumulation of amyloid-beta peptide (Aβ) aggregates in the brain that lead to severe synaptic and cognitive dysfunctions resulting in neurodegenerative ...
Synthesis, characterization and cytotoxicity of Pd(II) complexes for the inhibition of cathepsin B
(Universidade Federal de São Carlos, 2021-12-13)
Cancer is one of the most dreaded diseases of the 20th century, and its prevalence and incidence are increasing in the 21st century. The situation is so serious that one in four people can develop cancer in their lifetime. ...
Novos complexos de Pd(II) contendo tiossemicarbazonas derivadas de o-vanilina: citotoxicidade e inibição das enzimas topoisomerase
(Universidade Federal de São Carlos, 2018-11-30)
In this work, the objective was to study new Pd(II) complexes with the general formula [PdCl(PR3)(TSC)], where PR3 is the triphenylphosphine ligand with para substituent: H, F, OCH3, CH3, and the chelating ligand (TSC) ...
Influência do grupo carboxílico na atividade citotóxica e na interação de novos complexos de rutênio com DNA e HSA
(Universidade Federal de São Carlos, 2016-02-25)
The purpose of this work is evaluate how the position of a free carboxyl group can affect the interaction with DNA and HSA, and the cytotoxic profile against tumor and normal cells and Mycobacterium tuberculosis, for a set ...
Síntese e caracterização de Complexos de Pd(II) com potencial atividade citotóxica e inibidores das enzimas Topoisomerase II
(Universidade Federal de São Carlos, 2018-05-29)
It is known that cancer is a set of more than 100 diseases which are the second largest cause of death in the world. There are several factors related to the growth of tumors, showing different pathway for the planning of ...
Citotoxicidade de complexos de rutênio contendo aminoácidos sulfurados em células tumorais
(Universidade Federal de São Carlos, 2016-07-28)
The work presents the synthesis and characterization of three new ruthenium II complexes containing sulfur amino acids, to evaluate the probable influence of the amino acids on the complexes cytotoxic activity. The complexes ...
Complexos fosfínicos de rutênio contendo o ligante 2,2’-dipiridilamina: síntese, caracterização e avaliação de suas atividades citotóxicas e de interação com DNA
(Universidade Federal de São Carlos, 2016-02-29)
This work aims the synthesis, characterization and evaluation of the biological activities of a series of mixed ligand ruthenium (II) phosphine complexes the containing 2,2’-dipyridylamine ligand. Furthermore, the studies ...
Estudo da influência de nanopartículas de ouro na atividade de lipase de Pseudomonas fluorescens imobilizada em nanopartículas superparamagnéticas
(Universidade Federal de São Carlos, 2020-02-19)
The growing interest in the application of biocatalysts in several industrial sectors made the enzymatic immobilization stand out among the possible strategies to enable the use of these catalysts. This strategy has the ...
Síntese e caracterização de complexos de Prata (I): investigação da citotoxidade e interação com o DNA
(Universidade Federal de São Carlos, 2020-06-23)
The inorganic compound, cisplatin, is used on a large scale to different types of cancer. This complex acts in DNA structure by covalent bonds. However, the chemotherapy agent presents several side effects and some tumors ...