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Estudo da atividade biológica do motivo ECD do domínio tipo-desintegrina da botropasina
(Universidade Federal de São Carlos, 2011-05-10)
Integrins are cell surface receptors that mediate cell adhesion and platelet aggregation, although they do part of important physiological processes in the organism, are also related pathologies such as tumorigenesis, ...
Ensaios bioquímicos e celulares para a identificação de novos inibidores de TcGAPDH seletivos à HsGAPDH
(Universidade Federal de São Carlos, 2011-08-11)
Chagas disease is a tropical neglected illness; nearly 10 million people are infected, in 2008 it was responsible for the deaths of about 10 thousand people. At present, only two medicines (benznidazol and nifurtimox) are ...
Planejamento de inibidores da cruzaína baseado em fragmentos
(Universidade Federal de São Carlos, 2011-07-27)
The Chagas disease, described in 1909 by the Brazilian sanitary physician, scientist and bacteriologist Dr. Carlos Chagas, is caused by the Trypanosomatid parasite Trypanosoma cruzi. Current treatments involve the use of ...
Emprego da organocatálise como uma ferramenta da química verde em reações de adição conjugada : estudos visando a síntese de anéis indólicos
(Universidade Federal de São Carlos, 2012-03-30)
Organocatalysis has emerged as a powerful synthetic paradigm and has accelerated the development of new methods to make diverse chiral molecules. In addition, the small chiral organic molecules used to accelerate asymmetric ...
Estudo químico e biológico de micro-organismos endofíticos associados às frutas banana, pêra e goiaba
(Universidade Federal de São Carlos, 2010-03-05)
Studies about interaction between microorganisms and plants are focused mainly in the vegetal tissues like roots, steam and leaves. Fruits are a right target for microorganism attacks. Nevertheless, endophytic microorganisms ...
Estudo do perfil químico de Cyperus rotundus e avaliação do seu potencial de absorção de metais
(Universidade Federal de São Carlos, 2016-07-27)
The following work describes the comparative study of the variation between chemical profiles of plants of the Cyperus rotundus species – where one was collected at Vale S.A.’s dumping ground in Canaã dos Carajás city, ...
Estudo fitoquímico de Conchocarpus marginatus (Rutaceae), e avaliação do potencial biológico dos compostos isolados
(Universidade Federal de São Carlos, 2013-03-27)
The specie Conchocarpus marginatus is native from Espírito Santo. This plant, that was recently reclassified by PIRANI e KALLUNKI, does not show chemical or biological data in literature yet. In this way, the phytochemical ...
Estudos sobre a síntese de ftalocianinas anfifílicas com baixa agregação em solução
(Universidade Federal de São Carlos, 2013-01-16)
The present dissertation describe the studies conducted on the synthesis and photophysical properties of phthalocyanine dyes. The main propose of this work was to produce amphiphilic structures with low aggregation in ...
Síntese de clorinas anfifílicas com potenciais aplicações em terapia fotodinâmica
(Universidade Federal de São Carlos, 2012-10-26)
The main objective of this work was to construct amphiphilic chlorins with low aggregation in a physiological environment. The synthesis and structural characterization of the target compounds were carried out, and preliminary ...
Desenvolvimento de métodos para estudo de dioxinas presentes na cinza do bagaço da cana-de-açúcar : avaliação do potencial biorremediador de cepas microbianas em compostagem aeróbica
(Universidade Federal de São Carlos, 2012-03-30)
Sugarcane bagasse ash is a byproduct of sugar and alcohol industry with potential for field application. However, the presence of organic contaminants such as dioxins turns necessary the development of strategies for removal ...