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Busca por inibidores de catepsinas em plantas do cerrado paulista e avaliação da proteólise tumoral in vitro
(Universidade Federal de São Carlos, 2015-03-27)
The aim of this work is search for cysteine proteases inhibitors using a bioactivity-guided assay. We have selected different plants for the initial screening. Among all evaluated extracts, the ones obtained from Myrcia ...
Estudo fitoquímico de Rauia sp e Conchocarpus macrophyllus (Rutaceae) e avaliação da atividade antiparasitária de extratos e substãncias isoladas.
(Universidade Federal de São Carlos, 2006-05-17)
This work involved the
study of plant extracts of the Rutaceae species. Among 16 extracts tested in assays
carried out with T. cruzi gGAPDH and L. tarentolae APRT enzymes and
trypomastigote forms of T. cruzi, four showed ...
Ressonância magnética nuclear ultrarrápida: implementação, desenvolvimento e aplicações
(Universidade Federal de São Carlos, 2011-11-24)
This work highlights the implementation, development and application of the Ultrafast Nuclear Magnetic Resonance (UFNMR) technique, proposed by Frydman and co-workers. Through this technique, it is possible to perform ...
Síntese e avaliação biológica de uma coleção de flavonóides
(Universidade Federal de São Carlos, 2009-05-29)
The flavonoids are an important class of polyphenolic compounds present in relative abundance among the secondary metabolites of plants and are found in fruits, vegetables, nuts, seeds, flowers, tea, honey and propolis. ...
Integração de métodos in silico e in vitro para o planejamento de inibidores da enzima cruzaína
(Universidade Federal de São Carlos, 2011-06-30)
Chagas disease, caused by the flagellate protozoan of the family Trypanosomatidae Trypanosoma cruzi, is endemic in Latin America. The available drugs are ineffective and cause severe side effects. Therefore, it is necessary ...
Reações multicomponentes de Diels-Alder com parabenzoquinonas : intermediários para Sesquiterpenos Eudesmanos
(Universidade Federal de São Carlos, 2010-09-20)
In the first part of this thesis we describe the study of the oxidation of phenols to p-benzoquinones. The metal complexes used as catalysts in this study are: [CoII(salen)], [CoII(dmsalen)], [CoII(salpn)], [CoII(dmsalpn)], ...
Síntese e avaliação da atividade biológica de compostos N-Heterocíclicos
(Universidade Federal de São Carlos, 2011-07-28)
N-heterocyclic compounds have a large number of biochemical and medical applications and an important role in the discovery of new drugs, and many of best sellers, currently in use, contains one or more N-heterocyclic ...
Estudo de metabólitos secundários de Ruta graveolens como inibidores da fotossíntese
(Universidade Federal de São Carlos, 2012-12-09)
In this work were isolated eighteen secondary metabolites from Ruta graveolens (Rutaceae), eleven alkaloids (five akridonic, five quinolinics and one quinolonic) and seven furanocoumarins. Thirteen compounds had their ...
Estudo químico em patógenos e vetores de doenças de citros: Xylella fastidiosa e Diaphorina citri
(Universidade Federal de São Carlos, 2011-07-04)
CHEMICAL STUDY OF PATHOGENS AND VECTORS DISEASE OF CITRUS: Xylella fastidiosa & Diaphorina citri. Historically the national citriculture suffered great changes because of phytosanitary problems, and nowadays among the main ...
Busca de substâncias bioativas em plantas amazônicas: Adiscanthus fusciflorus (Rutaceae), Trichilia pallida e T. rubra (Meliaceae)
(Universidade Federal de São Carlos, 2004-08-12)
The aim of this
work was the search for antiparasitic and insecticide compounds in active extracts
from the following amazon plants: A. fusciflorus (Rutaceae), T pallida e T. rubra
(Meliaceae). The selected biological ...