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Estudo de produtos naturais e derivados sintéticos buscando inibidores seletivos das catepsinas L e V
(Universidade Federal de São Carlos, 2011-01-31)
The present work describes the search of bioactive secondary metabolites in plant species of genus Zanthoxylum and synthetic derivatives seeking specific inhibitors of cathepsins L and V. The natural products are involved ...
Avaliação de parâmetros de desempenho de três modelos de biorreatores pneumáticos de bancada
(Universidade Federal de São Carlos, 2010-02-25)
Due to the large number of functional advantages, pneumatic bioreactors have drawn attention in the biotechnology field, being more promising than stirred and aerated tank bioreactors. Parameters such as global gas hold-up ...
Secagem de resíduos cítricos em secador rotativo
(Universidade Federal de São Carlos, 2011-03-03)
In this present work, an experimental study about simultaneous heat and mass transfer phenomena was carried out during the drying process of citric solid waste in a direct-heat contact semi-pilot rotary dryer, operating ...
Transformações na matéria orgânica nos sedimentos e águas eutrofizados da Represa Ibirité (Ibirité-Sarzedo, MG) tratados com nitrato de cálcio em microcosmos
(Universidade Federal de São Carlos, 2010-11-19)
Due to the growing concern with the environment and the welfare of future generations the search for the restoration of degraded areas and the reestablishment of equilibrium between the anthropogenic and natural environments ...
Complexos de metais de transição para o desenvolvimento de novas drogas neuroativas
(Universidade Federal de São Carlos, 2010-02-26)
The biological role and pharmacological utility of histamine and 4-aminopyridine in the physiological medium has led us to the development of luminescent and photolabile metal-histamine and metal-4-aminopyridine donor that ...
Complexos de cobre (II) com bases de Schiff tridentadas, tipo ONN e tetradentadas simétricas e assimétricas, tipo ONNO: síntese e caracterização e estudos como catalisadores na oxidação de catecóis
(Universidade Federal de São Carlos, 2011-03-23)
Salen-type complexes are an important class of coordination compounds and are used as catalysts in various homogeneous and heterogeneous systems. Complexes of transition metals participate in many chemical processes, which ...
Ensaios bioquímicos e celulares para a identificação de novos inibidores de TcGAPDH seletivos à HsGAPDH
(Universidade Federal de São Carlos, 2011-08-11)
Chagas disease is a tropical neglected illness; nearly 10 million people are infected, in 2008 it was responsible for the deaths of about 10 thousand people. At present, only two medicines (benznidazol and nifurtimox) are ...
Perovskitas baseadas no PZT e PLZT sintetizadas usando o método dos complexos oxidantes de peróxido (OPM)
(Universidade Federal de São Carlos, 2011-03-17)
Were synthesized by the OPM, the solid solutions of Pb(Zr1-xTix)O3 with x = 0.8, 0.48 and 0.2, and also the lanthanum modified lead zirconate titanate compositions (Pb0.95La0.05) (Zr1-xTix)O3 with x = 0.8 and 0.2. This ...
Avaliação das atividades citotóxicas de alguns complexos fosfínicos de rutênio (Células tumorais MDA-MB 231)
(Universidade Federal de São Carlos, 2010-04-05)
In this thesis complexes of general formula: [Ru(NS)(bipy)(PP)]PF6 (NS = 2-mercaptopyridine, 2-mercaptopyrimidine, 4,6-dimethyl-2- mercaptopyrimidine and PP = dppf, dppp, dppe); [Ru(pic)(bipy)(PP)]PF6 (pic = picolinate; ...
Metátese de fechamento de anel: espiro-anelação estereosseletiva / Reações multicomponentes de Diels-Alder na síntese de compostos tricíclicos
(Universidade Federal de São Carlos, 2011-02-22)
In this work, a study of different synthetic ways was made in order to obtain spiro compounds starting from R-(-)-carvone, getting to the formation of cycloheptenone as an intermediate, which undergoes two consecutives ...