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Planejamento e avaliação de fragmentos moleculares como inibidores da enzima cruzaína
(Universidade Federal de São Carlos, 2015-08-24)
The available drugs for treating Chagas disease are not
effective, therefore the development of new therapies is needed. Cruzain is the major
Trypanosoma cruzi cysteine protease, the causative agent of the disease, and ...
Multicomponent reactions in the discovery of organocatalysts and the diversification of organocatalytic approaches
(Universidade Federal de São Carlos, 2015-06-19)
This thesis reports the development of multicomponent approaches directed to specific objectives: a) the discovery of new and efficient peptide-based catalyst for asymmetric
transformations and b) the synthesis of ...
Busca por inibidores de catepsinas em plantas do cerrado paulista e avaliação da proteólise tumoral in vitro
(Universidade Federal de São Carlos, 2015-03-27)
The aim of this work is search for cysteine proteases inhibitors using a bioactivity-guided assay. We have selected different plants for the initial screening. Among all evaluated extracts, the ones obtained from Myrcia ...
Estudo do perfil químico de Cyperus rotundus e avaliação do seu potencial de absorção de metais
(Universidade Federal de São Carlos, 2016-07-27)
The following work describes the comparative study of the variation between chemical profiles of plants of the Cyperus rotundus species – where one was collected at Vale S.A.’s dumping ground in Canaã dos Carajás city, ...
Estudos fitoquímicos e avaliação da atividade antitumoral de extratos vegetais de Casearia sylvestris nanoencapsulados
(Universidade Federal de São Carlos, 2013-03-26)
The term cancer refers to neoplasias that are characterized by uncontrolled growth of cells that have some kind of genetic mutation. Prostate cancer is the cancer with the highest incidence in men. In its initial phase, ...
Químio-, régio- e estereosseletividades das reações de Diels-Alder de para-benzoquinonas: um estudo teórico
(Universidade Federal de São Carlos, 2014-07-23)
In this work, some computational theoretical studies on the reactivity of para-benzoquinones and their derivatives in Diels-Alder reactions were proposed These studies were done in order to compliment the corresponding ...
Técnicas de bioinformática aplicadas ao estudo de poligalacturonases de fungos
(Universidade Federal de São Carlos, 2012-04-18)
Plant cell walls are composed of approximately 65% cellulose microfibrils and pectin. The latter is proteolytically degraded by the so-called pectinases enzymes (also known as pectinolytic enzymes). Pectinases may be either ...
Metátese de fechamento de anéis de derivados da R-(-)- Carvona
(Universidade Federal de São Carlos, 2012-03-21)
In this work was developed a new synthetic route to obtain cicloeptenone not conjugated selectively, through a faster and simpler methodology, and in accordance with good practices of green chemistry. By experimental ...
Síntese de uma coleção de cumarinas, possíveis inibidores da enzima acetilcolinesterase
(Universidade Federal de São Carlos, 2010-08-13)
Alzheimer's disease is associated with decreased rates of acetylcholine (ACh) in synaptic process, decreasing the cortical cholinergic transmission, and other neurotransmitters such as norepinephrine, dopamine, serotonin, ...
Identificação e estudo do fungo Mucor circinelloides isolado do tronco de Pinus taeda, com ênfase em biotransformação da carvona
(Universidade Federal de São Carlos, 2012-03-28)
Identification and study of the fungus Mucor circinelloides isolated from the trunk of Pinus taeda, with emphasis on the carvone biotransformation. Fungi associated with plants have been studied ripping seeking the discovery ...