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Identificação assistida por docking molecular de potenciais alvos em Plasmodium falciparum para derivados de indol-3-glioxiltirosina com atividade antimalárica in vitro
(Universidade Federal de São Carlos, 2020-07-28)
Malaria, although it is no longer considered a neglected disease, remains a public health problem. In 2018 alone, the World Health Organization estimated 228 million new cases and 405,000 deaths worldwide. Currently, ...
Supramolecular synthesis and characterization of new multicomponent forms of fluconazole
(Universidade Federal de São Carlos, 2020-06-30)
Active Pharmaceutical Ingredient (API) is the therapeutic constituent that defines the pharmacological properties and performance of the drug. Their qualities vary due to their respective physicochemical and pharmacological ...
Complexos semi-sanduíche de RuII/areno e produtos naturais: uma promissora combinação para novos metalofármacos
(Universidade Federal de São Carlos, 2020-10-15)
This thesis presents the synthesis, characterization and evaluation of antitumor activity of nineteen neutral and monocatonic organometallic complexes containing ligands derived from natural products. The complexes were ...
Estudos bioquímicos e cinéticos de acetilcolinesterases de formigas cortadeiras (Atta sexdens)
(Universidade Federal de São Carlos, 2017-09-29)
Acetylcholinesterase (AChE) (EC 3.1.1.7) is the enzyme responsible for catalyzing the hydrolysis of the neurotransmitter acetylcholine leading to the release of acetate and choline. In insects, acetylcholine is one of the ...
Tetra(tien-2-il)porfirina e seus complexos com metais da primeira-série de transição: síntese, caracterização, investigação da citotoxicidade e interação com DNA
(Universidade Federal de São Carlos, 2020-07-21)
Cancer is a generic term for over 100 diseases with uncontrolled cell growth. Each year, all cancer forms are responsible for millions of deaths worldwide and are the leading cause of deaths linked to disease. Therefore, ...
Reações fotoquímicas promovidas por luz visível para a síntese de compostos heterocíclicos
(Universidade Federal de São Carlos, 2017-07-27)
In the last decades, the emphasis and application of the principles of Green Chemistry have inspired a change of behavior, both in industry and academy, towards a more sustainable chemistry aiming the synthesis of the ...
Síntese de miméticos da urease de Canavalia ensiformis e avaliação mecanística da decomposição da ureia
(Universidade Federal de São Carlos, 2020-02-20)
Urease is a metalloenzyme found in many different organisms, which is also associated to virulence factors, such as pielonefritis. Hence, the study of urease inhibitors is necessary to control its activity. For a better ...
Busca de substâncias inseticidas e fungicidas para controle de formigas-cortadeiras através do estudo fitoquímico biomonitorado de espécies de Picramnia e avaliação da atividade bacteriostático em Xanthomonas citri subsp citri
(Universidade Federal de São Carlos, 2019-10-31)
The search for insecticide and fungicide substances to control leaf-cutting ants through biomonitored phytochemical study of Picramnia species and evaluation of bacteriostatic activity in Xanthomonas citri. Subsp citri. ...
Abordagem investigativa como fator de motivação em três cursos da área de Química de uma instituição pública do Estado de São Paulo
(Universidade Federal de São Carlos, 2020-08-07)
Laboratory classes have great potential to motivate students in science courses, whether to learn new knowledge or to demonstrate what they have already learnt. There are some ways of working in the laboratory and two draw ...
Estudo espectroscópico por FTIR da conversão de etanol em catalisadores de Au suportados
(Universidade Federal de São Carlos, 2020-07-25)
In this work, an FTIR spectroscopic study of gold catalysts supported on monoclinic zirconia (with Au content of 2,5% w/w), was carried out in order to elucidate the surface nature of this catalyst in the dehydrogenation ...