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Planejamento de inibidores da cruzaína baseado em fragmentos
(Universidade Federal de São Carlos, 2011-07-27)
The Chagas disease, described in 1909 by the Brazilian sanitary physician, scientist and bacteriologist Dr. Carlos Chagas, is caused by the Trypanosomatid parasite Trypanosoma cruzi. Current treatments involve the use of ...
Caracterização de quatro espécies de quebra-pedra utilizando cromatografia líquida de alta eficiência hifenada a espectrometria de massa em múltiplos estágios
(Universidade Federal de São Carlos, 2011-05-18)
This work presents the results of the use of High Performance Liquid Chromatography coupled to mass spectrometry in the chemical differentiation/characterization of aqueous extracts of plant samples of the genus Phyllanthus, ...
Estudos de separação enantiosseletiva para uma série de sulfóxidos quirais em colunas poliméricas
(Universidade Federal de São Carlos, 2010-03-12)
The liquid chromatography enantiomeric separation of a series of seventeen chiral sulfoxides was systematically investigated using multimodal elution with the new synthetic polymeric stationary phases based on monomers ...
Estudo químico e biológico de micro-organismos endofíticos associados às frutas banana, pêra e goiaba
(Universidade Federal de São Carlos, 2010-03-05)
Studies about interaction between microorganisms and plants are focused mainly in the vegetal tissues like roots, steam and leaves. Fruits are a right target for microorganism attacks. Nevertheless, endophytic microorganisms ...
Estudo de produtos naturais e derivados sintéticos buscando inibidores seletivos das catepsinas L e V
(Universidade Federal de São Carlos, 2011-01-31)
The present work describes the search of bioactive secondary metabolites in plant species of genus Zanthoxylum and synthetic derivatives seeking specific inhibitors of cathepsins L and V. The natural products are involved ...
Complexos de metais de transição para o desenvolvimento de novas drogas neuroativas
(Universidade Federal de São Carlos, 2010-02-26)
The biological role and pharmacological utility of histamine and 4-aminopyridine in the physiological medium has led us to the development of luminescent and photolabile metal-histamine and metal-4-aminopyridine donor that ...
Transformações na matéria orgânica nos sedimentos e águas eutrofizados da Represa Ibirité (Ibirité-Sarzedo, MG) tratados com nitrato de cálcio em microcosmos
(Universidade Federal de São Carlos, 2010-11-19)
Due to the growing concern with the environment and the welfare of future generations the search for the restoration of degraded areas and the reestablishment of equilibrium between the anthropogenic and natural environments ...
Ensaios bioquímicos e celulares para a identificação de novos inibidores de TcGAPDH seletivos à HsGAPDH
(Universidade Federal de São Carlos, 2011-08-11)
Chagas disease is a tropical neglected illness; nearly 10 million people are infected, in 2008 it was responsible for the deaths of about 10 thousand people. At present, only two medicines (benznidazol and nifurtimox) are ...
Perovskitas baseadas no PZT e PLZT sintetizadas usando o método dos complexos oxidantes de peróxido (OPM)
(Universidade Federal de São Carlos, 2011-03-17)
Were synthesized by the OPM, the solid solutions of Pb(Zr1-xTix)O3 with x = 0.8, 0.48 and 0.2, and also the lanthanum modified lead zirconate titanate compositions (Pb0.95La0.05) (Zr1-xTix)O3 with x = 0.8 and 0.2. This ...
Complexos do tipo cis-[Ru(L-phen)2(apy)2]2+ com interesse no tratamento de Mal de Alzheimer: propriedades físico-químicas e estudos de inibição da Acetilcolina Esterase
(Universidade Federal de São Carlos, 2011-04-15)
The photochemical and photophysical properties of the cis-[Ru(phen)2(4apy)2]2+ complex where 4apy= 4-aminopyridine are reported. In this work the complexes are thermically stable throughout the course of many hours in ...