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Desenvolvimento de imunossensores microfluídicos descartáveis para detecção de biomarcadores visando o diagnóstico precoce da doença de Alzheimer
(Universidade Federal de São Carlos, 2019-03-25)
Alzheimer's disease (AD) is a neurodegenerative condition that affects a large number of elderly and has an important social and economic impact. In early stages, the AD diagnosis can significantly improve patients' quality ...
Arginase: da imobilização à modulação de ensaios de afinidade em coleções de produtos naturais
(Universidade Federal de São Carlos, 2019-05-17)
ARGINASE: FROM THE IMMOBILIZATION TO MODULATION OF AFFINITY ASSAY IN COLLECTIONS OF NATURAL PRODUCTS. The use of natural products from plants dates from antiquity and they are often targets as they exhibit biological ...
Desenvolvimento de potenciais metalofármacos de rutênio contendo 1,1’-bis(difenilfosfino)ferroceno e ligantes mercapto
(Universidade Federal de São Carlos, 2019-02-25)
The antimetastatic activity, high selectivity and cytotoxicity in various human tumor cell line makes ruthenium (II) complexes attractive for the development of new chemotherapeutic agents for cancer treatment. In this ...
Avaliação da atividade bactericida e antineoplásica de novos complexos de Ag(I) contendo semicarbazonas e trifenilfosfina como ligantes
(Universidade Federal de São Carlos, 2019-09-27)
Title: EVALUATION OF BACTERIAL ACTIVITY AND ANTINEOPLASTIC OF NEW Ag(I) COMPLEXES CONTAINING SEMICARBAZONES AND TRIPHENYLPHOSPHINES AS LIGANDS. The present work aimed to evaluate the influence of ligands triphenylphosphine ...
Papaína imobilizada em partículas magnéticas: novos modelos de triagem de ligantes
(Universidade Federal de São Carlos, 2019-03-29)
Cathepsins, human lysosomal enzymes, are associated with the development of various diseases, and cruzaine is an important enzyme in the development of the protozoan Trypanosoma cruzi, causes Chagas' disease. Cysteine ...
Levantamento de modelos mentais para verificação de aprendizagem significativa do conceito de equilíbrio químico em licenciandos em química
(Universidade Federal de São Carlos, 2019-08-23)
The concept of equilibrium corresponds to one of the most complex and difficult topics of teaching and understanding in Chemistry. Although different researches has adopted the theme as an object of research and the important ...
Obtenção de inseticidas e fungicidas a partir de Picramnia Glazioviana e bagaço de laranjas para o controle de formigas cortadeiras
(Universidade Federal de São Carlos, 2019-02-26)
Because our country has a continental dimension and a very suitable climate for practicing numerous varieties of crops, it is necessary to obtain adequate control of the pests that afflict food production. One of the main ...
Synthesis of g-C3N4/Nb2O5 heterostructures: study of photocatalytic properties
(Universidade Federal de São Carlos, 2019-04-22)
Semiconductors are promising catalysts for artificial photosynthesis, but to date, there is no consensus on the ideal photocatalyst for CO2 reduction. Among semiconductors used for CO2 reduction, Nb2O5 is a promising ...
Modificação covalente de peptideos antimicrobianos e anticancerigenos para a melhoria de suas propriedades farmacológicas
(Universidade Federal de São Carlos, 2019-08-16)
Following the information obtained by a rational design study, cyclic and dimeric helical stabilized analogues of the peptide Cm-p5 were synthetized. The cyclic monomer showed an increased activity in vitro ...
Estudo de complexos metálicos de RuII, NiII, PdII e PtII com ligantes aciltioureias: atividade citotóxica e interação com biomoléculas
(Universidade Federal de São Carlos, 2019-12-20)
In this work, two series of phosphine complexes containing acylthiourea ligands were synthesized, characterizatied and evaluatied of the cytotoxic activities. The first series of compounds was composed of complexes with ...