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Estudo de novas metodologias para realização de ensaios com a catepsina D na busca de inibidores
(Universidade Federal de São Carlos, 2015-02-06)
Cathepsin D is an aspartyl endopeptidase involved in many pathological processes when overexpressed. In addition, it is responsible for degradation of hemoglobin ingested by parasites of schistosomiasis. For these reasons ...
Planejamento e avaliação de fragmentos moleculares como inibidores da enzima cruzaína
(Universidade Federal de São Carlos, 2015-08-24)
The available drugs for treating Chagas disease are not
effective, therefore the development of new therapies is needed. Cruzain is the major
Trypanosoma cruzi cysteine protease, the causative agent of the disease, and ...