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Estudo de novas metodologias para realização de ensaios com a catepsina D na busca de inibidores
(Universidade Federal de São Carlos, 2015-02-06)
Cathepsin D is an aspartyl endopeptidase involved in many pathological processes when overexpressed. In addition, it is responsible for degradation of hemoglobin ingested by parasites of schistosomiasis. For these reasons ...
Multicomponent reactions in the discovery of organocatalysts and the diversification of organocatalytic approaches
(Universidade Federal de São Carlos, 2015-06-19)
This thesis reports the development of multicomponent approaches directed to specific objectives: a) the discovery of new and efficient peptide-based catalyst for asymmetric
transformations and b) the synthesis of ...
Busca por inibidores de catepsinas em plantas do cerrado paulista e avaliação da proteólise tumoral in vitro
(Universidade Federal de São Carlos, 2015-03-27)
The aim of this work is search for cysteine proteases inhibitors using a bioactivity-guided assay. We have selected different plants for the initial screening. Among all evaluated extracts, the ones obtained from Myrcia ...